Suppressor Effector Function of CD4+CD25+ Immunoregulatory T Cells Is Antigen Nonspecific

By A. Thornton, E. Shevach. Journal of Immunology, 2000

1,476 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/c3faac5070a4d02d0c95d1e602dfa06e16d5a778

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In Immunology

1. E. Shevach
2. C. Piccirillo
3. D. Munn
4. A. Mellor
5. M. Levings
6. P. Krammer
7. Angelika Schmidt
8. Nina Oberle

Citations in the corpus

• Human Cd25+Cd4+ T Regulatory Cells Suppress Naive and Memory T Cell Proliferation and Can Be Expanded in Vitro without Loss of Function (2001, background): “In addition, CD25 CD4 Tr cells may act by downregulating the expression of CD80 and CD86 on APCs (19), although some reports suggest that APCs are not required for the suppressive activity and indicate that direct T cell–T cell interaction is involved (17).”
• Cutting Edge: Control of CD8+ T Cell Activation by CD4+CD25+ Immunoregulatory Cells (2001, methodology): “1 Address correspondence and reprint requests to Dr. Ethan M. Shevach, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10, Room 11N311, 10 Center Drive, Bethesda, Maryland 20892-1892.”
• Regulatory T Cells Induced by 1α,25-Dihydroxyvitamin D3 and Mycophenolate Mofetil Treatment Mediate Transplantation Tolerance1 (2001, background): “CD4 CD25 cells suppress immune responses via non-Ag specific mechanisms that appear to be independent from the production of immunoregulatory cytokines (4, 58), although the alloantigen-specific regulatory T cells contained within the CD45RB population have been found to require IL-10 for functional”
• Natural Recovery and Protection from Autoimmune Encephalomyelitis: Contribution of CD4+CD25+ Regulatory Cells within the Central Nervous System1 (2005, background): “Tregs that have recently been activated or expanded in vitro are more potent than resting Tregs (27, 31, 32); indeed, the CD4 CD25 cells in the CNS appear phenotypically more highly activated in the CNS than in the LN.”
• Increase of regulatory T cells in the peripheral blood of cancer patients. (2003, result): “Both groups showed an enhanced antiproliferative effect on CD4 CD25 T cells, which is in line with recent reports showing an increase of the suppressive activity of Tregs after in vitro expansion (21).”
• CD4+CD25+ regulatory T cells down‐regulate co‐stimulatory molecules on antigen‐presenting cells (2000, result): “These data might at first glance seem contradictory to those of Thornton and Shevach [11] who studied the expression of CD86 on B cells after co-culture with CD4 + CD25 + T cells.”
• Induction of Interleukin 10–Producing, Nonproliferating Cd4+ T Cells with Regulatory Properties by Repetitive Stimulation with Allogeneic Immature Human Dendritic Cells (2000, result): “Thus, human IL-10–producing T cells induced by repetitive stimulations with iDCs showed many similarities to the murine CD41CD251 T cells described by Thornton and Shevach (38).”