Cutting Edge: Control of CD8+ T Cell Activation by CD4+CD25+ Immunoregulatory Cells

By C. Piccirillo, E. Shevach. Journal of Immunology, 2001

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Mechanisms of foxp3+ T regulatory cell-mediated suppression. (2009, positive): “…of the response of transgenic CD8+ T cells to stimulation with MHC class I peptide tetramers by preactivated Treg cells was readily observed in the absence of a source of professional APC, suggesting that Treg cells could also efficiently target responder T cells (Piccirillo and Shevach, 2002).”
Increased regulatory T-cell fraction amidst a diminished CD4 compartment explains cellular immune defects in patients with malignant glioma. (2006, background): “Tregs also inhibit IFN-g production (13, 14) and prompt target cells to secrete predom-”
CD8+ T Cell Immunity Against a Tumor/Self-Antigen Is Augmented by CD4+ T Helper Cells and Hindered by Naturally Occurring T Regulatory Cells (2005, methodology): “Sorted Treg and Th cell subsets were separately activated with anti-CD3 and IL-2 as previously described (26) and then cocultured with either anti-CD3-activated (0.”