Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2).

By P. Revy, T. Muto, Y. Lévy, F. Geissmann, A. Plebani, O. Sanal, Nadia Catalan, M. Forveille, R. Dufourcq-Lagelouse, A. Gennery and 11 more. Cell, 2000

1,572 citations recorded by the source corpus.

Subfields: Genetics, Immunology

View Paper: https://www.semanticscholar.org/paper/c358107314738a61eb1e77e4e450db258cfaacc1

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. R. Dalla-Favera
2. Yi Zhang
3. U. Klein
4. Frédéric Chedin
5. M. Lieber
6. Susan C. Wu

In Immunology

1. A. Cerutti
2. J. Chaudhuri
3. M. Lieber
4. F. Alt
5. R. Dalla-Favera
6. Tasuku Honjo
7. Yi Zhang
8. Theam Soon Lim

Citations in the corpus

• Naïve Human Antibody Libraries for Infectious Diseases (2018, background): “AID is a 24 kDa protein that deaminates cytidine residues on single-stranded DNA (ssDNA), not RNA or double stranded DNA (dsDNA) [23] .”
• R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells (2003, background): “What enzyme activity might cleave class switch regions? Activation-induced deaminase (AID) is a protein of 24 kDa that is essential for both CSR and somatic hypermutatio”
• Transcription-targeted DNA deamination by the AID antibody diversification enzyme (2003, background): “jpg" NDATA ITEM> ]> Activation-induced cytidine deaminase (AID), which is specific to B lymphocytes, is required for class switch recombination (CSR)—a process mediating isotype switching of immunoglobulin—and somatic hypermutation—the introduction of many point mutations into the immun”
• Retroviral restriction by APOBEC proteins (2004, background): “Although somatic hypermutation, gene conversion and class-switch recombination seem, overtly, to be very different, they are linked by an absolute requirement for AI”
• Induction of activation‐induced cytidine deaminase gene expression by IL‐4 and CD40 ligation is dependent on STAT6 and NFκB (2004, methodology): “Preparation and culture of human B cells and B cell lines Human peripheral blood mononuclear cells (PBMC) were purified from heparinized blood obtained with informed consent from healthy adults by density gradient centrifugation on Ficoll-Hypaque as described previously ( 22 ).”
• Activation-induced Deaminase (AID)-directed Hypermutation in the Immunoglobulin Sμ Region (2002, background): “Therefore, it is striking that a defect of AID, a putative RNA editing enzyme, virtually abolishes both SHM and CSR without affecting germinal center formation (10, 11).”
• Germinal centres: role in B-cell physiology and malignancy (2008, background): “and requires the activity of activation-induced cytidine deaminase (AID”
• Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. (2000, background): “Although our knowledge about other mole- HIGM2 patients (Revy et al., 2000 [this issue of Cell]).”