Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro.
By Nick Barker, Meritxell Huch, P. Kujala, M. van de Wetering, Hugo J. G. Snippert, J. van Es, Toshiro Sato, D. Stange, H. Begthel, Maaike van den Born and 8 more. Cell Stem Cell, 2010
1,552 citations recorded by the source corpus.
View Paper: https://www.semanticscholar.org/paper/c2bc3ce19d11027e89cf1cb857d0cc73a7258323
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
- Hans Clevers
- E. Batlle
- J. Drost
- C. Bevins
- Z. Steinhart
- D. Tuveson
- Giulia Biffi
- Norman Sachs
Citations in the corpus
- Wnt/β-catenin signaling and disease. (2012, unknown): “Labeled stem cells have been detected in organs ranging from the intestine to the stomach, the skin, the hair follicle, and the mammary gland (Barker et al., 2007; Barker et al., 2010; van Amerongen et al., 2012).”
- Microfluidic 3D cell culture: from tools to tissue models. (2015, background): “Stem cells expressing the LGR5 receptor have been identified which have been shown to maintain stemness in vitro and differentiate into fully functional intestine, stomach and liver [56–58].”
- Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells. (2010, unknown): “In the colon, stomach, and hair follicle, Lgr5hi cells have also been identified as stem cells (Barker et al., 2007, Barker et al., 2010; Jaks et al., 2008), whereas the Lgr6 gene marks a population of primitive skin stem cells (Snippert et al., 2010).”
- Modeling Development and Disease with Organoids. (2016, background): “With slight modifications to the mini-gut culture system, single Lgr5 cells efficiently generated long-term, continuously expanding organoids closely resembling mature pyloric epithelium (Barker et al., 2010).”
- Identification of multipotent luminal progenitor cells in human prostate organoid cultures (2014, background): “…3D culture conditions that allow long-term expansion of primary mouse and human epithelial Cell 159, 163–175, September 25, 2014 ª2014 Elsevier Inc. 163 organoids from small intestine (Sato et al., 2009), colon (Sato et al., 2011), stomach (Barker et al., 2010), and liver (Huch et al., 2013).”
- Organoid cultures derived from patients with advanced prostate cancer (2014, unknown): “Indeed, others have reported that the growth conditions used here are broadly conducive to growth ofmultiple normal epithelial cell types (Barker et al., 2010; Huch et al., 2013a; Huch et al., 2013b; Sato et al., 2009).”