Modeling Development and Disease with Organoids.

By Hans Clevers. Cell, 2016

2,765 citations recorded by the source corpus.

Subfields: Molecular Biology, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/00d843dacfea994752fa67f1754c0ca20927374e

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In Molecular Biology

In Pulmonary and Respiratory Medicine

Sigrid A. Langhans

Citations in the corpus

Obstacles and opportunities in the functional analysis of extracellular vesicle RNA – an ISEV position paper (2017, background): “nisation.[229] Indeed, 2D-grown cellsmay not recapitulate certain features required for proper release or reception of functional EV-RNA (e.”
Three-Dimensional in Vitro Cell Culture Models in Drug Discovery and Drug Repositioning (2018, background): “Over the past decade, the term organoid has broadened and now encompasses a variety of tissue culture techniques that result in self-organizing, self-renewing 3D cultures derived from primary tissue, embryonic stem cells, or induced pluripotent stem cells that have a similar functionality as the tis”
A Patient-Derived Glioblastoma Organoid Model and Biobank Recapitulates Inter- and Intra-tumoral Heterogeneity. (2019, background): “Recently, 3D organoid culture systems have been developed that capture the phenotypic and molecular heterogeneity found in various organs (Clevers, 2016), including cerebral organoids (Kadoshima et al., 2013; Lancaster et al., 2013; Paşca et al., 2015; Qian et al., 2016).”
Genetics and biology of prostate cancer (2018, background): “Organoids, however, are limited by the lack of TME components (Clevers 2016), which may be addressed through coculture with other cell types in order to better model cancer cell–TME cross-talk in vitro.”
A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity. (2018, neutral): “Organoids can be established from healthy as well as diseased donors (including cancer) and recapitulate the epithelial architecture and physiology of the organs they were isolated from (Clevers, 2016).”