Human Endothelial Progenitor Cells From Type II Diabetics Exhibit Impaired Proliferation, Adhesion, and Incorporation Into Vascular Structures

By Oren M Tepper, R. Galiano, Jennifer M. Capla, C. Kalka, P. Gagne, G. Jacobowitz, J. Levine, G. Gurtner. Circulation, 2002

1,545 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/c2a8b064b48eb9643cae48d1a4a9dc798be046a2

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Citations in the corpus

Therapeutic stem and progenitor cell transplantation for organ vascularization and regeneration (2003, background): “In type II diabetes, recruitment of EPCs to neoangiogenic sites is diminishe”
Impaired progenitor cell activity in age-related endothelial dysfunction. (2005, background): “Indeed, several studies demonstrated that the number of circulating EPCs inversely correlated with risk factors for coronary artery disease, such as smoking, family history of coronary artery disease, hypertension (34), and diabetes mellitus ( 35 ).”
Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells (2003, background): “Indeed, patients at risk for developing coronary artery disease have significantly reduced numbers of circulating EPC”
Circulating endothelial progenitor cells are reduced in peripheral vascular complications of type 2 diabetes mellitus. (2005, positive): “Both type 1 and type 2 DM have been associated with low levels and poor function of circulating EPCs (16,17); however, no data are available on the relationships between EPC pathophysiology and vascular complications of DM.”
Topical vascular endothelial growth factor accelerates diabetic wound healing through increased angiogenesis and by mobilizing and recruiting bone marrow-derived cells. (2004, background): “We have recently shown that EPCs from human diabetics are functionally impaired.(21) This impairment in EPC function may provide an explanation for the other vascular defects common to diabetics, such as reduced collateral formation or the embryonic vasculopathy seen in the offspring of diabetic mot”
Drug Delivery Systems and Materials for Wound Healing Applications (2018, positive): “For example in diabetic patients, endothelial cells are less responsive and usually take longer to form functional vasculature in the wound bed [213, 214].”
Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1 (2004, methodology): “We investigated the potential impact of reduced oxygen tension on SDF-1 regulation in vivo by using a model of soft-tissue ischemia in athymic nude mic”
Endothelial progenitor cell dysfunction: a novel concept in the pathogenesis of vascular complications of type 1 diabetes. (2004, neutral): “Indeed, studies have demonstrated that, in patients with cardiovascular risk factors, the number of EPCs that can be isolated from peripheral blood is reduced (6) and EPC function is impaired (7,8).”
Endothelial Dysfunction and Diabetes: Effects on Angiogenesis, Vascular Remodeling, and Wound Healing (2012, background): “There are numerous studies that have demonstrated, in patients with diabetes and cardiovascular disease, that the number of EPCs from peripheral blood is reduced and EPC function impaired [73, 88, 236, 237].”