Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells

By Alexandra Aicher, C. Heeschen, Christiane Mildner-Rihm, C. Urbich, C. Ihling, K. Technau‐Ihling, A. Zeiher, Stefanie Dimmeler. Nature Medicine, 2003

1,426 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/613f520ecd474914b216f206f74893f1064e4f0b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. Rakesh K. Jain
2. U. Förstermann
3. W. Sessa

In Molecular Biology

1. Dai Fukumura
2. Rakesh K. Jain
3. S. Kashiwagi
4. Shahin Rafii
5. J. Liao
6. A. Tedgui
7. E. Schiffrin
8. Z. Mallat

In Physiology

1. Rakesh K. Jain
2. G. King
3. A. Tedgui
4. E. Schiffrin
5. Z. Mallat
6. U. Förstermann

Citations in the corpus

• Nitric oxide synthases: regulation and function. (2012, background): “Reduced systemic NO bioactivity seen in ischaemic heart disease may therefore contribute to impaired neovascularization.(92)”
• Endothelial Dysfunction and Diabetes: Effects on Angiogenesis, Vascular Remodeling, and Wound Healing (2012, background): “These alterations in NO signaling might contribute to modulation of postischemic neovascularization because NO is a well-known mediator of BM-MNC mobilization and differentiation, as well as basal neovascularization reaction [85].”
• Endothelial dysfunction. (2004, background): “It is interesting that eNOS expression by bone marrow stroma cells plays an essential role in the recruitment of endothelial progenitor cells (145).”
• The Role of MicroRNAs in Human Diseases (2010, background): “Recently it was demonstrated that eNOS also plays a major role in the mobilization and functional activity of stem cells (68 - 70) ; therefore, designing miRNAs to target eNOS is thought to regulate vasculogenesis (62) .”
• The role of nitric oxide in tumour progression (2006, background): “showed that defects in angiogenesis and reperfusion in ischaemic tissues of eNos −/− mice could be rescued by injection of stem/progenitor cells that were derived from wild-type mic”
• Pleiotropic effects of statins. (2005, result): “These findings agree with earlier data showing that statins rapidly mobilize EPCs from the bone marrow and accelerate vascular structure formation via activation of phosphatidylinositol 3kinase (PI3K)/protein kinase Akt and eNOS (55,74,76).”
• The SDF-1-CXCR4 signaling pathway: a molecular hub modulating neo-angiogenesis. (2007, background): “Remarkably, activation of MMP-9 and subsequent release of sKitL and mobilization of pro-angiogenic cells are impaired in eNOS−/− mice, delineating a new role for the NO signaling pathway in SDF-1-induced BM cell mobilization [37].”
• Vascular complications of diabetes: mechanisms of injury and protective factors (2013, background): “Differentiation of EPC from bone-marrow-derived cells may also play a role (Tamarat et al., 2004). eNOS is necessary for mobilization of EPC from the bone marrow, as this phenomenon is impaired in eNOS knockout mice (Aicher et al., 2003).”
• Cytokines in atherosclerosis: pathogenic and regulatory pathways. (2006, background): “eNOS is a potent proangiogenic mediator (5), previously shown to limit atherosclerosis development (346).”