Topical vascular endothelial growth factor accelerates diabetic wound healing through increased angiogenesis and by mobilizing and recruiting bone marrow-derived cells.

By R. Galiano, Oren M Tepper, Catherine R Pelo, Kirit A. Bhatt, M. Callaghan, N. Bastidas, S. Bunting, Hope Steinmetz, G. Gurtner. American Journal of Pathology, 2004

778 citations recorded by the source corpus.

Subfields: Molecular Biology, Orthopedics and Sports Medicine, Rehabilitation

View Paper: https://www.semanticscholar.org/paper/d33e4e6cc8770e351b17551826f65b4c81b3a284

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Uzoagu A Okonkwo
2. M. Tomic‐Canic
3. L. DiPietro
4. J. Costerton
5. M. Shirtliff

In Rehabilitation

1. L. DiPietro
2. M. Tomic‐Canic
3. Uzoagu A Okonkwo
4. R. Frykberg
5. Jaminelli Banks

Citations in the corpus

• Polymicrobial Interactions: Impact on Pathogenesis and Human Disease (2012, background): “broblast migration, and macrophage function (59, 65, 66, 130).”
• Diabetes and Wound Angiogenesis (2017, background): “also identified this deficit, and went on to show that wounds of db/db mice treated with VEGF-A exhibited accelerated wound closure compared to untreated mice [85].”
• Pathogenesis and Treatment of Impaired Wound Healing in Diabetes Mellitus: New Insights (2014, neutral): “Basic fibroblast growth factor (bFGF), recombinant human epidermal growth factor (rh-EGF), recombinant human vascular endothelial growth factor (rhVEGF), nerve growth factor (NGF) and growth factors isolated at high concentrations from platelet rich plasma (PRP) also have been used as a treatment to”
• Mesenchymal Stem Cell Exosomes Induce Proliferation and Migration of Normal and Chronic Wound Fibroblasts, and Enhance Angiogenesis In Vitro (2015, background): “In contrast, chronic nonhealing wounds exhibit decreased production of growth factors and chemokines [6], reduced angiogenesis [7], decreased proliferation and reduced migration of fibroblasts [8,9], and an impaired inflammatory response [10].”
• Recent advances on the development of wound dressings for diabetic foot ulcer treatment--a review. (2013, background): “wound site to accelerate wound healing Galiano et al, 2004 [257]”
• Therapeutic Strategies for Enhancing Angiogenesis in Wound Healing (2018, background): “Application of VEGF-A towounds in db/dbmice increasedwound closure and angiogenesis [123].”
• PERSPECTIVE ARTICLE: Growth factors and cytokines in wound healing (2008, positive): “Other in vivo experiments show that show that VEGF-A improves reepithelialization of diabetic wounds associated with enhanced vessel formation.(209) Despite these improvements, however, exogenous administration of VEGF induces sustained vascular leakage and promotes the formation of disorganized blo”
• Factors affecting wound healing (2010, background): “In animal studies, therapeutic restoration of VEGF has been shown to improve repair outcomes significantly (Kirchner et al., 2003; Galiano et al., 2004).”