Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1

By Daniel J Ceradini, Anita R Kulkarni, M. Callaghan, Oren M Tepper, N. Bastidas, M. Kleinman, Jennifer M. Capla, R. Galiano, J. Levine, G. Gurtner. Nature Medicine, 2004

2,756 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/5b7b0b77d5ba2abd5bab10011846e44ffb78e9c9

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In Cancer Research

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2. G. Semenza
3. M. C. Simon
4. A. Mantovani
5. Zena Werb
6. Richard J. Johnson
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In Molecular Biology

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In Oncology

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4. P. Allavena
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7. G. Semenza
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Citations in the corpus

• Role of tumor-associated macrophages in tumor progression and invasion (2006, background): “Moreover, a recent work has shown that HIF-1 activation may play a role in the induction of the CXCR4 ligand, CXCL12 [45], a chemokine involved in cancer metastasis [46].”
• HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion. (2008, background): “Supported by recent data that ischemic tissues may recruit endothelial progenitors and other CXCR4+ BMDCs, in part through increases in HIF and its targets SDF1a and VEGF (Aghi et al., 2006; Ceradini et al., 2004; De Falco et al., 2004; Petit et al., 2007), here we test the hypothesis that hypoxic”
• Hypoxia-induced angiogenesis: good and evil. (2011, background): “Recent studies have demonstrated how hypoxia and the HIF pathway, through the modulation of angiogenic genes, such as Vegf (Table 3 and Figure 3), regulate the adult vascular system in numerous pathological conditions.(88,112-116) Not surprisingly, the HIF pathway represents an attractive therapeuti”