Normalization of obesity-associated insulin resistance through immunotherapy

By M. Ruth. 2010

812 citations recorded by the source corpus.

Subfields: Epidemiology, Immunology, Physiology

View Paper: https://www.semanticscholar.org/paper/c273ec3deeeff8416b91b832d9d5b5dd1dc6e78c

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In Epidemiology

In Immunology

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Citations in the corpus

Macrophage-mediated inflammation in metabolic disease (2011, background): “Two recent papers have provided evidence for the activation of pathogenic adaptive immune responses in diet-induced obesit”
Fat Tissue, Aging, and Cellular Senescence (2010, background): “Transplantation of anti-inflammatory TH2 cells into lymphocytedeficient mice reverses insulin resistance and MCP-1 owing to a high-fat diet (Winer et al., 2009).”
Adipokines in inflammation and metabolic disease (2011, background): “CD8 + effector T cells and T H 1 cell-associated factors can initiate the recruitment and activation of macrophages in adipose tissues and promote a pro-inflammatory cascade that is associated with insulin resistanc”
The NALP3/NLRP3 Inflammasome Instigates Obesity-Induced Autoinflammation and Insulin Resistance (2011, background): “Nlrp3 inflammasome regulates adipose-T cells in obesity In addition to macrophages, the expanded adipose tissue during obesity also harbors activated T cell populations that are thought to participate in local adipose tissue inflammation and insulin resistanc”
Regulatory T Cells: Mechanisms of Differentiation and Function (2012, background): “A role for Treg cells in opposing metabolic inflammation in fat tissue was also suggested by another group (233).”
Glucose Metabolism Regulates T Cell Activation, Differentiation, and Functions (2014, background): “Moreover, the prominence of immune cells in controlling inflammatory-associated inflammation such as obesity has now gained considerable attention (60).”
The cellular and signaling networks linking the immune system and metabolism in disease (2012, background): “T cells in adipose tissue are believed to play a part in obesity-induced inflammation by modifying ATM numbers and their activation stat”
Cellular and Molecular Players in Adipose Tissue Inflammation in the Development of Obesity-induced Insulin Resistance (2013, positive): “Furthermore, reconstitution of these mice with Foxp3 CD4 T cells or CD4 T cells from Il10 knockout mice resulted in the same degree of improvement in obesity-induced insulin resistance as reconstitution with total CD4 T cells [83].”
Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease (2010, neutral): “…(and recruitment of professional immune cells to this site) (Alexaki et al., 2009; Feuerer et al., 2009; Liu et al., 2009; Nishimura et al., 2009; Winer et al., 2009), whether triggered metabolically or through injury or death of adipocytes, can be linked to a diverse set of stress responses…”
Impact of Obesity and Metabolic Syndrome on Immunity. (2016, background): “The reduction in certain lymphocyte subsets may coincide with concomitant increases in T cells that respond to antigens unique to dysfunctional adipose and lymphocytes that favor metabolic tissue infiltration and proinflammatory responses (13, 20).”