The cellular and signaling networks linking the immune system and metabolism in disease

By O. Osborn, Jerrold M. Olefsky. Nature Medicine, 2012

1,499 citations recorded by the source corpus.

Subfields: Epidemiology, Immunology, Physiology

View Paper: https://www.semanticscholar.org/paper/6ecae67a4129ac8cdb8c2b6b7b39c6b6945e2e2f

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Citations in the corpus

Macrophages, immunity, and metabolic disease. (2014, background): “In addition, it is thought that if the magnitude of cytokine production is great enough, they can ‘‘leak’’ out of the adipose tissue and potentiate insulin resistance in an endocrine fashion in peripheral tissues such as muscle and liver (Osborn and Olefsky, 2012).”
Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity (2013, background): “Proc Natl Acad Sci USA 109(2):594–599.”
Cellular and Molecular Players in Adipose Tissue Inflammation in the Development of Obesity-induced Insulin Resistance (2013, neutral): “Many molecular mechanisms are proposed, including ER stress, oxidative stress, dysregulation of lipid homeostasis (including FFA homeostasis), mitochondrial dysfunction, hypoxia and others [5].”
Understanding the somatic consequences of depression: biological mechanisms and the role of depression symptom profile (2013, background): “Nutrition overload causes adipocytes to become hypertrophic and to secrete chemo-attractant proteins, which lead to recruitment of macrophages that produce their own pro-inflammatory cytokines and chemokines, attracting additional macrophages and setting up a feed-forward inflammatory process [66].”
Understanding the Mysterious M2 Macrophage through Activation Markers and Effector Mechanisms (2015, background): “For instance, sustaining the M2-like state of some tissue resident macrophages, such as Kupffer cells and adipose tissue macrophages, would diminish the production of inflammatory mediators and thus may be a therapeutic approach to treat metabolic diseases [3, 17].”
Vitamin C and Immune Function (2017, background): “Supplementation of healthy human volunteers with 1 g/day vitamin C (with and without vitamin E) was shown to enhance peripheral blood mononuclear cell-derived IL-10, IL-1, and TNF-α following stimulation with LPS [87,94].”
Role of the Microbiota in Immunity and inflammation (2014, background): “These inflammatory cytokines inhibit insulin signaling, leading to insulin resistance and increased blood sugar (Osborn and Olefsky, 2012).”