Functions of plasmalogen lipids in health and disease.

By N. Braverman, A. Moser. Biochimica et Biophysica Acta, 2012

998 citations recorded by the source corpus.

Plasmalogens are a unique class of membrane glycerophospholipids containing a fatty alcohol with a vinyl-ether bond at the sn-1 position, and enriched in polyunsaturated fatty acids at the sn-2 position of the glycerol backbone. These two features provide novel properties to these compounds. Although plasmalogens represent up to 20% of the total phospholipid mass in humans their physiological roles have been challenging to identify, and are likely to be particular to different tissues, metabolic processes and developmental stages. Their biosynthesis starts in peroxisomes, and defects at these steps cause the malformation syndrome, Rhizomelic Chondrodysplasia Punctata (RCDP). The RCDP phenotype predicts developmental roles for plasmalogens in bone, brain, lens, lung, kidney and heart. Recent studies have revealed secondary plasmalogen deficiencies associated with more common disorders and allow us to tease out additional pathways dependent on plasmalogen functions. In this review, we present current knowledge of plasmalogen biology in health and disease.

Subfields: Immunology, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/c2051339ec98abbb78b19fa7027f9034cd3e58f1

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Citations in the corpus

A new pathway for mitochondrial quality control: mitochondrial‐derived vesicles (2014, methodology): “Phospholipids like phosphatidylethanolamine, which is used to generate plasmalogens (Braverman & Moser, 2012), and perhaps even very long-chain fatty acids that may be misdirected to the mitochondria could be carried more easily within MDVs rather than via a soluble, cytosolic intermediate.”
COMPARTMENTS: unification and visualization of protein subcellular localization evidence (2014, result): “In contrast to the well-studied metabolic cooperation between the peroxisomes and the endoplasmic reticulum (41, 42), the connection to mitochondria was only recently discovered (43, 44), and the underlying mechanistic link is not yet fully understood (45).”