Arc/Arg3.1 is essential for the consolidation of synaptic plasticity and memories.

By N. Plath, Ora Ohana, B. Dammermann, M. Errington, D. Schmitz, C. Gross, X. Mao, A. Engelsberg, Claudia Mahlke, H. Welzl and 16 more. Neuron, 2006

867 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Neurology

View Paper: https://www.semanticscholar.org/paper/e228745a9f037e24a7ce4baaf72070f54271cfef

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. L. Mucke
2. J. Palop
3. Richard L. Huganir
4. J. Shepherd
5. Š. Kubík
6. Teiko Miyashita
7. R. Hen
8. John Guzowski

In Cognitive Neuroscience

1. Š. Kubík
2. Teiko Miyashita
3. L. Mucke
4. J. Palop
5. R. Hen
6. Attila Losonczy
7. Richard L. Huganir
8. John Guzowski

In Neurology

1. Š. Kubík
2. Teiko Miyashita
3. Richard L. Huganir
4. R. Hen
5. John Guzowski
6. C. Bramham
7. L. Mucke
8. A. Kreitzer

Citations in the corpus

• Hippocampal Memory Traces Are Differentially Modulated by Experience, Time, and Adult Neurogenesis (2014, background): “1, has been widely implicated in synaptic plasticity and HPC- dependent memory (Link et al., 1995; Lyford et al., 1995; Plath et al., 2006).”
• Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease. (2007, positive): “…or Arc in otherwise healthy rodents elicits neuronal deficits and memory impairments (Guzowski et al., 2000; He et al., 2002; Molinari et al., 1996; Plath et al., 2006; Tzingounis and Nicoll, 2006), the depletion of these factors could further contribute to granule cell dysfunction and behavioral…”
• Arc/Arg3.1 interacts with the endocytic machinery to regulate AMPA receptor trafficking. (2006, background): “These mice are viable and do not exhibit gross changes in brain architecture (Plath et al., 2006).”
• Dendritic mRNA: transport, translation and function (2007, background): “Mice in which these genes have been knocked out have defects in LTP maintenance and/or memory consolidatio”
• Using immediate-early genes to map hippocampal subregional functions. (2007, background): “Together, these find- 759www.learnmem.org Learning & Memory ings indicate that Arc plays an essential role in the stabilization of activity-dependent synaptic plasticity and synaptic consolidation (Guzowski et al. 2000; Guzowski 2002; Plath et al. 2006).”
• Synaptic signaling by all-trans retinoic acid in homeostatic synaptic plasticity (2008, background): “Unlike input-specific synaptic plasticity (i.e., LTP and LTD), homeostatic synaptic plasticity is generally believed to be triggered by a global change in neuronal activity that involves modification of all synapses (Thiagarajan et al., 2005; Turrigiano et al., 1998; Turrigiano and Nelson, 2004).”
• Translational control of long-lasting synaptic plasticity and memory. (2009, neutral): “1 knockout mice (Plath et al., 2006), and Arc/Arg3.”