Rules for making human tumor cells.

By William C. Hahn, R. Weinberg. New England Journal of Medicine, 2002

980 citations recorded by the source corpus.

Subfields: Cancer Research, Cell Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/c1d36654da2dffc3cb42a301402819f555215a15

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Citations in the corpus

An epigenetic switch involving NF-κB, Lin28, let-7 microRNA, and IL6 links inflammation to cell transformation (2009, neutral): “The molecular events governing the onset and progression of malignant transformation involve the inactivation of tumor suppressor genes and the acquisition of oncogenic mutations (Hahn and Weinberg, 2002; Vogelstein and Kinzler, 2004).”
A review on the dietary flavonoid kaempferol. (2011, background): “It is widely accepted that the formation of a malignant tumor requires that tumor cells acquire several capabilities (the socalled hallmarks of cancer), such as apoptosis resistance, increased angiogenesis, or capacity of invasion and metastasis [118, 119].”
Akt Stimulates Aerobic Glycolysis in Cancer Cells (2004, background): “Individual oncogenes and tumor suppressors have been classified based on their contributions to these cancer pathways (6).”
Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression (2004, background): “Tumorigenesis is a multistep process in which cells accumulate disparate complementing mutations that permit them to escape normal cellular and environmental constraints on proliferation (reviewed in Hanahan and Weinberg, 2000; Hahn and Weinberg, 2002).”
Advances in understanding cancer genomes through second-generation sequencing (2010, background): “In general, experimental validation of the function of mutations by approaches such as transformation assays”
Hematopoiesis: a human perspective. (2012, background): “As a result, human cells are more resistant to transformation (Hahn and Weinberg, 2002).”
Species- and cell type-specific requirements for cellular transformation. (2004, background): “Introduction human cell types to undergo transformation to a tumorigenic state (Hahn et al., 1999; Hahn and Weinberg, 2002b).”
Dual role of hydrogen peroxide in cancer: possible relevance to cancer chemoprevention and therapy. (2007, background): “Besides, it is considered that genetic instability is a key event that enables the acquisition of these capabilities [24,25].”
Cellular senescence in cancer and aging. (2007, neutral): “Loss of these tumor suppressors is essential for achieving oncogenic transformation of human cells in vitro (Hahn and Weinberg, 2002), and indeed these pathways are frequently disrupted in human cancer cells (Gil and Peters, 2006; Kim and Sharpless, 2006).”
Heat shock proteins in cancer: diagnostic, prognostic, predictive, and treatment implications (2005, background): “Finally, the process of carcinogenesis involves a complex array of genetic and epigenetic alterations, which contribute to cancer pathogenesis (Hahn and Weinberg 2002), leading ultimately to a unique cancer tissue (often with mixed cancer clones) within a unique molecular milieu and in this may…”
Modelling breast cancer: one size does not fit all (2007, background): “Furthermore, there is an ongoing debate as to whether the same genetic alterations transform both mouse and human epithelial cell”