Mechanisms of fear extinction

By Karyn M. Myers, Michael Davis. Molecular Psychiatry, 2007

1,255 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Neurology

View Paper: https://www.semanticscholar.org/paper/c1babfb73c05c1bea0d508ad8e14c8f336eb4df0

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In Cellular and Molecular Neuroscience

In Cognitive Neuroscience

In Neurology

Citations in the corpus

Optimizing inhibitory learning during exposure therapy. (2008, methodology): “Although there may be additional mechanisms at play during extinction learning (Myers & Davis, 2007), it is the inhibitory mechanisms which explain the discrepancies between extinction training and post-extinction fear levels.”
Emotion Regulation and the Anxiety Disorders: An Integrative Review (2010, background): “Neurobehavioral research demonstrates that the amygdala may mediate behavioral, cognitive, and physiological indicators of fear (e.g., Davis & Whalen, 2001; Myers & Davis, 2007).”
Preventing Mental, Emotional, and Behavioral Disorders Among Young People: Progress and Possibilities (2009, background): “Extinction is cue-specific, in that extinction to one CS does not induce or accompany extinction to another CS (Myers and Davis, 2007).”
Acceptance and mindfulness-based therapy: new wave or old hat? (2008, background): “For example, there is now good evidence that extinction learning, which appears to be a crucial element in exposure therapies for anxiety disorders, involves interactions between the medial prefrontal cortex and the amygdale (Myers & Davis, 2007).”
Optimizing Exposure Therapy for Anxiety Disorders: An Inhibitory Learning and Inhibitory Regulation Approach (2015, background): “It is now thought that inhibitory learning is central to extinction [Bouton, 1993; Miller and Matzel, 1988; Wagner, 1981], although additional mechanisms, such as habituation, may be at play as well [Myers and Davis, 2007].”
Neural Mechanisms of Extinction Learning and Retrieval (2008, background): “An excellent recent review focuses on molecular and pharmacological findings (Myers and Davis, 2007).”
Don't fear ‘fear conditioning’: Methodological considerations for the design and analysis of studies on human fear acquisition, extinction, and return of fear (2017, positive): “…2004; Bouton, 2014; Delamater, 2004, for cellular and molecular pathways mediating extinction learning which have mainly been studied in animal research see Fitzgerald et al., 2014; Herry et al., 2010; Milad and Quirk, 2012; Myers and Davis, 2002; Myers and Davis, 2007; Tovote et al., 2015).”
Memory engrams: Recalling the past and imagining the future (2020, background): “However, other accounts stress that extinction does not reflect unlearning the original association (perhaps by silencing the original engram) but rather reflects learning a new “conditioned stimulus–no unconditioned stimulus” association (185, 186) with a corresponding new extinction engram.”
AMYGDALA MICROCIRCUITS CONTROLLING LEARNED FEAR (2014, background): “Rather, extinction leads to the formation of a new inhibitory memory that competes with the initial fear memory for control of behavior (Bouton et al., 2006; Myers and Davis, 2007).”
Extinction circuits for fear and addiction overlap in prefrontal cortex. (2009, background): “In recent years, there have been great advances in our understanding of the neural circuitry responsible for this form of inhibitory learning (for reviews, see Cammarota et al. 2005; Maren 2005; Myers and Davis 2007; Quirk and Mueller 2008).”
How Does Mindfulness Meditation Work? Proposing Mechanisms of Action From a Conceptual and Neural Perspective (2011, positive): “After extinction training, extinction memory is thought to compete with conditioned memory for control of fear expression (Myers & Davis, 2007).”
Neurobiological Basis of Failure to Recall Extinction Memory in Posttraumatic Stress Disorder (2009, background): “It has been hypothesized that fear extinction and its retention are deficient in PTSD due to failure to activate brain extinction circuitry, including hippocampus and vmPFC (31,42).”
Slow-Wave Sleep-Imposed Replay Modulates Both Strength and Precision of Memory (2014, background): “…of odor input to circuits mediating fear extinction, such as amygdala and prefrontal cortex (Gottfried and Dolan, 2004; Sotres-Bayon et al., 2006; Myers and Davis, 2007; Maren, 2011) may be depressed during SWS, although extinction to contextual cues can occur during SWS (Hauner et al., 2013),…”