Slow-Wave Sleep-Imposed Replay Modulates Both Strength and Precision of Memory
By Dylan C. Barnes, D. Wilson. 2014
99 citations recorded by the source corpus.
Odor perception is hypothesized to be an experience-dependent process involving the encoding of odor objects by distributed olfactory cortical ensembles. Olfactory cortical neurons coactivated by a specific pattern of odorant evoked input become linked through association fiber synaptic plasticity, creating a template of the familiar odor. In this way, experience and memory play an important role in odor perception and discrimination. In other systems, memory consolidation occurs partially via slow-wave sleep (SWS)-dependent replay of activity patterns originally evoked during waking. SWS is ideal for replay given hyporesponsive sensory systems, and thus reduced interference. Here, using artificial patterns of olfactory bulb stimulation in a fear conditioning procedure in the rat, we tested the effects of imposed post-training replay during SWS and waking on strength and precision of pattern memory. The results show that imposed replay during post-training SWS enhanced the subsequent strength of memory, whereas the identical replay during waking induced extinction. The magnitude of this enhancement was dependent on the timing of imposed replay relative to cortical sharp-waves. Imposed SWS replay of stimuli, which differed from the conditioned stimulus, did not affect conditioned stimulus memory strength but induced generalization of the fear memory to novel artificial patterns. Finally, post-training disruption of piriform cortex intracortical association fiber synapses, hypothesized to be critical for experience-dependent odor coding, also impaired subsequent memory precision but not strength. These results suggest that SWS replay in the olfactory cortex enhances memory consolidation, and that memory precision is dependent on the fidelity of that replay.
Subfields: Cognitive Neuroscience, Endocrine and Autonomic Systems, Sensory Systems
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Citations in the corpus
- Cellular and Systems Consolidation of Declarative Memory (2017, unknown): “…(hippocampus (Wilson and McNaughton 1994), striatum (Pennartz et al. 2004), VTA (Gomperts et al. 2015), olfactory/prefrontal/visual/motor cortex (Barnes and Wilson 2014; Ji and Wilson 2007; Peyrache et al. 2009; Ramanathan et al. 2015; Yang et al. 2014) and disrupting sharp-wave-ripples and…”
- Synaptic Mechanisms of Memory Consolidation during Sleep Slow Oscillations (2016, background): “…(SWS) has been shown to facilitate consolidation of declarative, hippocampus-dependent memory (Gais et al., 2000; Marshall et al., 2006; Marshall and Born, 2007; Barnes and Wilson, 2014), whereas rapid eye movement (REM) sleep can benefit procedural, hippocampus-independent memory (Born, 2010).”