AMYGDALA MICROCIRCUITS CONTROLLING LEARNED FEAR
By Sevil Duvarci, Denis Paré. Neuron, 2014
682 citations recorded by the source corpus.
We review recent work on the role of intrinsic amygdala networks in the regulation of classically conditioned defensive behaviors, commonly known as conditioned fear. These new developments highlight how conditioned fear depends on far more complex networks than initially envisioned. Indeed, multiple parallel inhibitory and excitatory circuits are differentially recruited during the expression versus extinction of conditioned fear. Moreover, shifts between expression and extinction circuits involve coordinated interactions with different regions of the medial prefrontal cortex. However, key areas of uncertainty remain, particularly with respect to the connectivity of the different cell types. Filling these gaps in our knowledge is important because much evidence indicates that human anxiety disorders results from an abnormal regulation of the networks supporting fear learning.
Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience
View Paper: https://www.semanticscholar.org/paper/dfbd4ddedfb2e4231750069d2f32d2bdf2707890
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Cellular and Molecular Neuroscience
In Cognitive Neuroscience
Citations in the corpus
- What Can Ethobehavioral Studies Tell Us About The Brain’s Fear System? (2016, background): “the basal nucleus (BA) for contextual CSs via the hippocampus [8,10].”
- Insects have the capacity for subjective experience (2016, background): “Although the medial pallium is weakly homologous to the mammalian amygdala, these structures principally possess feedforward circuits that execute nociceptive defensive behaviours (Broglio et al., 2005; Duvarci and Pare, 2014; Janak and Tye, 2015).”