Microbiota is essential for social development in the mouse

By L. Desbonnet, G. Clarke, F. Shanahan, Ted G. Dinan, J. Cryan. Molecular Psychiatry, 2013

820 citations recorded by the source corpus.

The microbiota–gut–brain axis is an emerging concept in modern medicine informed by the ability of gut microbiota to alter brain and behaviour.1 Although some clinical studies have revealed altered gut microbiota composition in patients with neurodevelopmental disorders such as autism,2, 3 the specific contributions of microbiota in early life to the development and programming of the various facets of social behaviour has not been investigated.

Subfields: Molecular Biology, Pharmacy, Social Psychology

View Paper: https://www.semanticscholar.org/paper/c1b1990d16e104d2885dca6383a4be87ce73d5b9

How researchers see this paper

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In Molecular Biology

1. J. Cryan
2. Ted G. Dinan
3. G. Clarke
4. S. Mazmanian
5. C. Stanton
6. T. Sampson
7. P. Kennedy
8. R. Stilling

In Pharmacy

1. J. Cryan
2. Ted G. Dinan
3. G. Clarke
4. S. Mazmanian
5. C. Stanton
6. T. Sampson
7. P. Kennedy
8. R. Stilling

In Social Psychology

1. J. Cryan
2. Ted G. Dinan
3. G. Clarke
4. S. Mazmanian
5. T. Sampson
6. R. Stilling
7. C. Stanton
8. R. Moloney

Citations in the corpus

• Gut microbiota depletion from early adolescence in mice: Implications for brain and behaviour. (2015, background): “, 2013), sociability (Desbonnet et al., 2014), and memory (Gareau et al.”
• The gut microbiome from patients with schizophrenia modulates the glutamate-glutamine-GABA cycle and schizophrenia-relevant behaviors in mice (2019, background): “For example, gut microbiota have been reported to be associated with alterations in anxiety (7), memory (8), cognition (9), and locomotor activity (10).”
• Microbial genes, brain & behaviour – epigenetic regulation of the gut–brain axis (2014, result): “Recent evidence suggests, albeit in relatively small cohorts, that ASDs may be associated with alterations in microbiota composition and metabolism (Critchfield et al. 2011; de Theije et al. 2011; Douglas-Escobar et al. 2013; Gondalia et al. 2012; Louis 2012; Macfabe 2012; Ming et al. 2012; Mulle et”
• Cognitive Impairment by Antibiotic-Induced Gut Dysbiosis: Analysis of Gut Microbiota-Brain Communication (2016, background): “Studies in germ-free (GF) mice have been crucial in establishing a causal role of the commensal gut microbiota in shaping brain function and behavior (Stilling et al., 2014a).”
• Targeting the Microbiota-Gut-Brain Axis: Prebiotics Have Anxiolytic and Antidepressant-like Effects and Reverse the Impact of Chronic Stress in Mice. (2017, neutral): “Sociability was assessed by the three-chambered social approach task (28,29) and the resident-intruder test (30) with minor modifications (see Supplement).”
• Short‐chain fatty acids: microbial metabolites that alleviate stress‐induced brain–gut axis alterations (2018, methodology): “The three-chamber sociability test was used to assess social preference and recognition and was conducted as previously described (Desbonnet et al. 2014).”
• Stress & the gut-brain axis: Regulation by the microbiome (2017, neutral): “Improved understanding of the developmental impact of microbiota perturbations on behaviours relevant to stress and cognitive-related disorders is sorely needed (Desbonnet et al., 2014; Foster and McVey Neufeld, 2013).”
• Microbiota in health and diseases (2022, background): “Preclinical studies have established that gut microbiota affects cognitive performance, repetitive behaviors, and social interactions in different animal models.(62,254,255) One of the plausible hypotheses about gut microbiota’s involvement in affecting neuronal disorders is described by stress-indu”
• Gut instincts: microbiota as a key regulator of brain development, ageing and neurodegeneration (2017, methodology): “2004), where a germ-free mouse was placed in the centre chamber with a familiar mouse in one chamber and a novel mouse in the other chamber (Desbonnet et al. 2014).”
• The microbiota modulates gut physiology and behavioral abnormalities associated with autism (2013, neutral): “, 2008) and social behavior (Desbonnet et al., 2013).”
• Microbial reconstitution reverses maternal diet-induced social and synaptic deficits in offspring (2016, neutral): “Confirming this hypothesis and in keeping with recent results (Desbonnet et al., 2014), social be- haviors were impaired in GFmice (Figures 3A–3D and S4A–S4D).”
• Breaking down the barriers: the gut microbiome, intestinal permeability and stress-related psychiatric disorders (2015, background): “In addition to the disorders mentioned in this review, preclinical evidence suggests that the gut microbiota modulates behaviors associated with neurodevelopmental disorders such as autism spectrum disorder and schizophrenia (Hsiao et al., 2013; Desbonnet et al., 2014; Mayer et al., 2014b).”
• The Central Nervous System and the Gut Microbiome (2016, background): “…in the cortex and hippocampus; BDNF levels were lower in the cortex and hippocampus Sudo et al., 2004 Germ-free animals reduced social behavior Desbonnet et al., 2014 Probiotic administration increased social behavior decreased expression of specific BDNF transcripts in the amygdala Arentsen…”
• Gut Microbes and the Brain: Paradigm Shift in Neuroscience (2014, background): “…traits; (2) models expressing a human genetic mutation associated with ASD; and (3) models with acquired behaviors resulting from various environmental insults either affecting the developing animal directly (Desbonnet et al., 2014; de Theije et al., 2014) or affecting the mother of ASD offspring.”