Arabidopsis SGS2 and SGS3 genes are required for posttranscriptional gene silencing and natural virus resistance.

By P. Mourrain, C. Beclin, T. Elmayan, F. Feuerbach, C. Godon, J. Morel, David Jouette, Anne-Marie Lacombe, Snezana Nikic, N. Picault and 4 more. Cell, 2000

1,129 citations recorded by the source corpus.

Subfields: Endocrinology, Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/c152fc8743b455faa7119ead012a9031001b2a7a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrinology

In Molecular Biology

In Plant Science

Citations in the corpus

Roles of plant small RNAs in biotic stress responses. (2009, background): “These functions require cofactors, including the putative RNA helicase SILENCING DEFECTIVE 3 (SDE3) and the coiled-coil domain protein SUPPRESSOR OF GENE SILENCING 3 (SGS3), necessary for RDR6-mediated suppression of RNA and DNA virus accumulation (7, 19, 50, 51).”
Biogenesis, Turnover, and Mode of Action of Plant MicroRNAs[OPEN] (2013, background): “Mourrain, P., et al. (2000). Arabidopsis SGS2 and SGS3 genes are”
Endogenous siRNA and miRNA targets identified by sequencing of the Arabidopsis degradome. (2008, positive): “The observation that SGS3, a factor required for posttranscriptional gene silencing and ta-siRNA accumulation [26–28], is required to stabilize TAS1a and TAS2 cleavage products [25] argues in favor of selective stabilization.”
Small RNAs and Their Roles in Plant Development (2009, background): “…protein that is required for transgene silencing and ta-siRNA production and that is proposed to bind to the substrates of RDR6 in vivo, does not affect the activity of RDR6 in vitro (Fukunaga & Doudna 2009, Mourrain et al. 2000, Peragine et al. 2004, Vazquez et al. 2004b, Yoshikawa et al. 2005).”
Review. Elimination of viruses in plants: twenty years of progress (2013, background): “The process was first observed and described during studies of healthy transgenic plants where silencing is activated by plant cells as a means of genic control against all sequences that have no homology with those of their genome, including those of viral origin which in this context would trigger”
SGS3 and SGS2/SDE1/RDR6 are required for juvenile development and the production of trans-acting siRNAs in Arabidopsis. (2004, background): “Mutations in these genes confer sensitivity to cucumber mosaic virus (Beclin et al. 2002) and cabbage leaf curl virus (Muangsan et al. 2004), indicating that one of their normal functions is to provide resistance to viral infection.”
Approaches to Minimize Variation of Transgene Expression in Plants (2005, background): “2004), a coiled-coil protein of unknown function (SGS3; Mourrain et al. 2000), a RNA helicase (SDE3; Dalmay et al.”
MicroRNAs as master regulators of the plant NB-LRR defense gene family via the production of phased, trans-acting siRNAs. (2011, background): “Since DCL2 and SGS3 are involved in both small RNA silencing and viral resistance (Mourrain et al. 2000), and we demonstrated a substantial network of miRNAs and resulting phasiRNAs that target NB-LRR genes, we propose that the suppression of the small RNA silencing system and disease resistance…”
Endogenous trans-acting siRNAs regulate the accumulation of Arabidopsis mRNAs. (2004, background): “One is not polyade- SGS2), and a protein of unknown function, SGS3 (Dalmay et al., 2000; Mourrain et al., 2000; Boutet et al. ,”
Perspective: machines for RNAi. (2005, background): “In Caenorhabditis elegans and fungi like Neurospora crassa and Schizosaccharomyces pombe, genes encoding RdRP enzymes are required for silencing (Cogoni and Macino 1999; Dalmay et al. 2000; Mourrain et al. 2000; Smardon et al. 2000; Sijen et al. 2001; Hall et al. 2002; Volpe et al. 2002).”