Unexpected evidence for active brown adipose tissue in adult humans.

By J. Nedergaard, T. Bengtsson, B. Cannon. American Journal of Physiology. Endocrinology and Metabolism, 2007

1,843 citations recorded by the source corpus.

Subfields: Cell Biology, Physiology, Rehabilitation

View Paper: https://www.semanticscholar.org/paper/c0ebdc65b63f055ddae59202cd1218977a9f9169

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. B. Spiegelman
2. S. Kajimura
3. Y. Tseng
4. C. R. Kahn
5. S. Gesta
6. P. Seale
7. J. Nedergaard
8. B. Cannon

In Physiology

1. S. Kajimura
2. B. Spiegelman
3. P. Seale
4. Y. Tseng
5. C. R. Kahn
6. S. Gesta
7. J. Nedergaard
8. B. Cannon

In Rehabilitation

1. S. Kajimura
2. B. Spiegelman
3. P. Seale
4. J. Nedergaard
5. Y. Tseng
6. Kosaku Shinoda
7. H. Ohno
8. B. Cannon

Citations in the corpus

• Brown and beige fat: Physiological roles beyond heat-generation (2015, background): “Human BAT Do humans have thermogenic brown and/or beige fat? And if so, do these tissues affect systemic metabolism in a meaningful way? Through the use of (18)F-fluoro-2-deoxy-d-glucose ((18)F-FDG) positron emission tomography computed tomography ((18)F-FDG-PET) imaging, it is now evident that huma”
• Brown and beige fat in humans: thermogenic adipocytes that control energy and glucose homeostasis. (2015, neutral): “Patterns of (18)F-FDG uptake in adipose tissue and muscle: a potential source of false-positives for PET.”
• Different metabolic responses of human brown adipose tissue to activation by cold and insulin. (2011, methodology): “272 Cell Metabolism 14, 272–279, August 3, 2011 a2011 Elsevier Inc (CT) for diagnostic imaging of metabolically active tumors and metastases, a confounding symmetrical pattern of increased metabolism is often observed in the supraclavicular region (Nedergaard et al., 2007).”
• Human BAT Possesses Molecular Signatures That Resemble Beige/Brite Cells (2012, background): “humans have significant amounts of active brown fat deposits [3,4,5,6,7,8,9].”
• UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality. (2009, background): “Second, although it had earlier been believed that active brown adipose tissue is only found in human newborns, recent years have seen an accumulation of unexpected evidence that adult humans also possess active brown adipose tissue (Nedergaard et al., 2007).”
• Developmental origin of fat: tracking obesity to its source. (2007, positive): “Indeed, [18F]-2-fluoro-D-2deoxy-D-glucose (FDG) positron emission tomography (PET) can detect areas of metabolically active brown fat in the cervical, supraclavicular, axillary, and paravertebral regions of normal individuals (Nedergaard et al., 2007) (Figure 1, bottom).”
• Protection from obesity and diabetes by blockade of TGF-β/Smad3 signaling (2011, background): “Brown fat and skeletal muscle share developmental origins (Seale et al., 2008), and metabolically active BAT stores exist in humans (Nedergaard et al., 2007), opening new therapeutic avenues for obesity and diabetes (Enerbäck, 2010; Nedergaard and Cannon, 2010).”
• High Incidence of Metabolically Active Brown Adipose Tissue in Healthy Adult Humans (2009, background): “These findings collectively suggest that the FDG uptake in adipose tissue at the specific regions reflects the metabolic activity of BAT (15).”