Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice

By N. Sakaguchi, Takeshi Takahashi, H. Hata, T. Nomura, Tomoyuki Tagami, S. Yamazaki, T. Sakihama, T. Matsutani, I. Negishi, S. Nakatsuru and 1 more. Nature, 2003

890 citations recorded by the source corpus.

Subfields: Immunology, Radiology, Nuclear Medicine and Imaging

View Paper: https://www.semanticscholar.org/paper/c0beab056b43c1302e5241f2fbf10d5637b15538

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Shimon Sakaguchi
2. T. Nomura
3. M. Ono
4. Carola G. Vinuesa
5. K. Takeda
6. S. Feske
7. M. Narazaki
8. E. Shevach

In Radiology, Nuclear Medicine and Imaging

1. M. Narazaki

Citations in the corpus

• Cellular and genetic mechanisms of self tolerance and autoimmunity (2005, background): “The tyrosine kinase ZAP70 (ζ-chain-associated protein kinase of 70 kDa) is required for thymocyte deletion because partial deficiency of ZAP70 in mice allows cells with forbidden TCRs to escape death and cause a systemic inflammatory disorder resembling rheumatoid arthriti”
• Foxp3+CD25+CD4+ natural regulatory T cells in dominant self‐tolerance and autoimmune disease (2006, background): “For example, SKG mice, which harbor a point mutation in the ZAP-70 gene (ZAP) on BALB/c background, spontaneously develop T-cell-mediated autoimmune arthritis with accompanied skewing of their TCR repertoire to high self-reactivity (107).”
• Calcium signalling in lymphocyte activation and disease (2007, background): “This hypothesis that failed negative selection is involved in the development of autoimmunity is supported by an in vivo model of rheumatoid arthritis, in which mutation of the kinase ZAP70 (ζ-chain-associated protein kinase of 70 kDa) results in strongly reduced (but not abrogated) TCR signals in”
• Dysbiosis Contributes to Arthritis Development via Activation of Autoreactive T Cells in the Intestine (2016, methodology): “SKG mice, which bear a point mutation in the ZAP-70 gene (Zap70), spontaneously develop Th17 cell2dependent arthritis in a conventional facility (7).”