Regulation of insulin action and pancreatic β-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1

By J. Nakae, W. Biggs, T. Kitamura, W. Cavenee, C. Wright, K. Arden, D. Accili. Nature Genetics, 2002

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Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liver. (2007, background): “Foxo1 gain-of-function, dominant negative inhibition, and generalized haploinsufficiency (Nakae et al., 2001, 2002) have shown impairment and potentiation, respectively, of insulin action on HGP.”
A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span. (2006, background): “In a similar vein, the role of FOXOs in pathological states including cancer and diabetes mellitus (Hu et al., 2004; Nakae et al., 2002) points to the possibility that misregulation of MST-FOXO signaling might contribute to the pathogenesis of these disorders.”
The role of FoxO in the regulation of metabolism (2008, background): “Consistent with these studies, FoxO1 haploinsufficiency is able to rescue the loss of insulin sensitivity in InsR haploinsuffcient mice in part by reducing hepatic expression of gluconeogenic genes (Nakae et al., 2002).”
Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression (2004, background): “teristic of these atrophying muscles (48).”