Somatic diversification of variable lymphocyte receptors in the agnathan sea lamprey

By Z. Pancer, C. Amemiya, Götz R. A. Ehrhardt, Jill Ceitlin, G. Gartland, M. Cooper. Nature, 2004

674 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/c0480fbdc7ae9064b4f6e4b2dc5abcb9530733a9

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In Immunology

Citations in the corpus

Origin and evolution of the adaptive immune system: genetic events and selective pressures (2010, result): “The discovery in jawless fish of a lymphoid cell-based system of adaptive immunity that is strikingly similar to the system in jawed fish was a total surpris”
Disease prevention and resistance in social insects: modeling the survival consequences of immunity, hygienic behavior, and colony organization (2007, background): “Although it has been possible to trace the phylogenetic roots of immune response in some vertebrate groups (e.g., Pancer et al. 2004), little is understood of the evolution of immunity and other methods of disease resistance and prevention in social insects.”
Trained immunity: a memory for innate host defense. (2011, background): “A RAG-independent rearrangement comes from the discovery of highly diverse leucine-rich repeats (LRRs) as a new type of variable lymphocyte receptor system in jawless vertebrates such as the lamprey (Pancer et al., 2004).”
MHC class I molecules and kirs in human history, health and survival (2005, background): “By contrast, the surviving species of jawless fish — lampreys and hagfish — lack the familiar molecules of adaptive immunity, but they might use other molecular systems for a similar purpos”
T cell– and B cell–independent adaptive immunity mediated by natural killer cells (2006, background): “Lymphocytes in agnathan vertebrates can generate variable lymphocyte receptors through gene rearrangements that do not involve RAG protein”
Are innate immune signaling pathways in plants and animals conserved? (2005, background): “The idea of a process of convergent evolution is also supported by the recombinatorial immune system in lampreys (a jawless vertebrate), which involves highly diverse LRRs instead of the immunoglobulin gene segments found in jawed vertebrate”
The evolution of adaptive immune systems. (2006, positive): “Activated lamprey lymphoblasts were instead found to express transcripts for leucine-rich-repeat (LRR) proteins in great abundance and, surprisingly, these proved to have highly variable amino acid sequences (Pancer et al., 2004a).”