Origin and evolution of the adaptive immune system: genetic events and selective pressures

By M. Flajnik, M. Kasahara. Nature reviews genetics, 2010

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Selectionist and Evolutionary Approaches to Brain Function: A Critical Appraisal (2012, background): “, 2001) Reinforcement learning (Sutton and Barto, 1998) Adaptive immune system (Flajnik and Kasahara, 2010)”
Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells (2011, background): “2077" language="eng" relation="no"> Immunoregulation is a highly evolved biologic response able to fine-tune inflammation and innate immunity but also able to modulate adaptive immunity and establish tolerance to sel”
IgT, a primitive immunoglobulin class specialized in mucosal immunity (2010, background): “However, these species lack immunoglobulins or T cell antigen receptors, both of which arose in jawed vertebrate”
Present Yourself! By MHC Class I and MHC Class II Molecules (2016, background): “These molecules are essential for cell-mediated immunity and therefore appeared at the inception of the adaptive immune system, some 500 million years ago[1].”