MHC class I molecules and kirs in human history, health and survival

By Peter Parham. Nature reviews. Immunology, 2005

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How researchers see this paper

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Targeting natural killer cells and natural killer T cells in cancer (2012, background): “These receptors and their ligands (H-2 molecules in mice and HLA molecules in humans) are highly polymorphic molecules encoded by multigenic, multiallelic families of genes that are inherited independentl”
Functions of natural killer cells (2008, background): “In particular, NK cells express MHC class I–specific receptors and 'lose' inhibitory signals when encountering MHC class I–deficient hematopoietic cells in several in vitro and in vivo model”
Immunology of placentation in eutherian mammals (2006, background): “KIR haplotypes comprise two groups, A and B, the main difference being that there are more activating receptors in the B haplotyp”
NK cells and cancer immunosurveillance (2008, background): “Some of these receptors exhibit similar specificities for MHC class I molecules as their sequence-related inhibitory counterparts, albeit these interactions are often of lower affinity (Lanier, 2005; Parham, 2005).”