GABA itself promotes the developmental switch of neuronal GABAergic responses from excitation to inhibition.

By Karunesh Ganguly, A. F. Schinder, Scott T. Wong, Mu-Ming Poo. Cell, 2001

727 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience

View Paper: https://www.semanticscholar.org/paper/c02408c277ce23cbc65e2c8484dc63f1c87c90f6

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In Cellular and Molecular Neuroscience

In Cognitive Neuroscience

Citations in the corpus

Is there more to gaba than synaptic inhibition? (2002, background): “Finally, a recent study in cultured hippocampal neurons provides intriguing evidence that GABA A -receptor-mediated signalling itself seems to produce the developmental [Cl − ] i switc”
Cation-chloride cotransporters and neuronal function. (2009, background): “An intriguing hypothesis suggests that presynaptically released GABA acts as a self-limiting trophic factor in a negative feedback loop where depolarizing postsynaptic GABA A R responses are required for the developmental upregulation of KCC2 (Ganguly et al., 2001; see also Leitch et al., 2005).”
Trans-synaptic shift in anion gradient in spinal lamina I neurons as a mechanism of neuropathic pain (2003, background): “What cellular mechanism underlies this shift in ∇ anion ? Recent studies at early developmental stages in the brain have shown a link between the expression of the potassium–chloride exporter KCC2 and neuronal [Cl - ] i”
Spontaneous network activity and synaptic development (2013, unknown): “Similarly, electrical connections among different sets of neurons contribute to stage I (embryonic day E17-P1) and stage III (P11-14) waves in the rodent retina (Akrouh and Kerschensteiner 2013; Catsicas and others 1998; Syed and others 2004; Wong and others 1998).”
Neuronal Differentiation in the Adult Hippocampus Recapitulates Embryonic Development (2005, background): “For instance, GABAergic transmission is known to play a trophic role during embryonic and early postnatal development (LoTurco et al., 1995; Marty et al., 1996; Ganguly et al., 2001; Ben Ari, 2002).”
Becoming a new neuron in the adult olfactory bulb (2003, background): “Early onset of GABAergic synapses on newborn neurons In many immature brain regions, the primary inhibitory transmitter in the mature brain, GABA, first provides excitatory drive in the embryonic or neonatal brai”
Editing modifies the GABAA receptor subunit α3 (2007, background): “However, if GABA itself promotes the expression of KCC2 is still under debate (Ganguly et al. 2001; Ludwig et al. 2003; Titz et al. 2003).”
GABA: a pioneer transmitter that excites immature neurons and generates primitive oscillations. (2007, background): “Ganguly er et al., 2001 Hippocampus Rat P1–9 In vivo P7–9 and slices P1–8 Field potentials, gramicidin perforated patch Depolarizing, blockade of NKCC1 renders GABA hyperpolarizing and blocks sharp waves in vivo and GDPs in vitro.”
Imbalance between GABAergic and Glutamatergic Transmission Impairs Adult Neurogenesis in an Animal Model of Alzheimer’s Disease (2009, unknown): “Previous findings showed that GABA itself promotes GABAergic responses from depolarization to hyperpolarization (Ganguly et al., 2001), which could prematurely reduce Ca influx and blunt dendritic growth.”
Modeling Hippocampal Neurogenesis Using Human Pluripotent Stem Cells (2014, background): “Finally, studies have also shown a transition in hippocampal granule neurons from a GABA-excitatory to a GABA-inhibitory state during early maturation as a result of changes in intracellular Cl concentration due to the upregulation of the KCC2 channel (Ganguly et al., 2001; Li et al., 2012).”
GABAergic Interneuron Dysfunction Impairs Hippocampal Neurogenesis in Adult Apolipoprotein E4 Knock-in Mice (2009, background): “However, in adult hippocampus, as in the embryonic nervous system, GABAergic neurotransmission in NSCs and immature neurons is excitatory, owing to their high intracellular concentration of chloride (Ganguly et al., 2001; Ge et al., 2006a, 2006b; Liu et al., 2006; Tozuka et al., 2005).”