LncRNA-mediated regulation of cell signaling in cancer
By Wan-Xin Peng, Pratirodh Koirala, Yin-yuan Mo. Oncogene, 2017
1,480 citations recorded by the source corpus.
To date, a large number of long non-coding RNAs (lncRNAs) have been recently discovered through functional genomics studies. Importantly, lncRNAs have been shown, in many cases, to function as master regulators for gene expression and thus, they can play a critical role in various biological functions and disease processes including cancer. Although the lncRNA-mediated gene expression involves various mechanisms, such as regulation of transcription, translation, protein modification, and the formation of RNA–protein or protein–protein complexes, in this review, we discuss the latest developments primarily in important cell signaling pathways regulated by lncRNAs in cancer.
Subfields: Cancer Research, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/ac6ae0080808b9e98dd9ab38a109af91340188fe
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In Molecular Biology
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Citations in the corpus
- The Need for Multi-Omics Biomarker Signatures in Precision Medicine (2019, background): “This includes alterations in DNA methylation [55], histone modifications [56], and expression of miRNAs [57] and lncRNAs [58,59].”