ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis

By K. Tobiume, A. Matsuzawa, Takumi Takahashi, H. Nishitoh, Kei-ichi Morita, K. Takeda, O. Minowa, K. Miyazono, Tetsuo Noda, H. Ichijo. EMBO Reports, 2001

1,250 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/bf1df9cc046ddf43b3ac1aff89e26fac68c4b625

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In Molecular Biology

1. K. Kregel
2. Hannah J. Zhang
3. M. Jäättelä
4. T. Suda
5. Keisuke Ito
6. E. Reddy
7. K. Matsumoto
8. J. Avruch

Citations in the corpus

• Tumor necrosis factor signaling (2003, background): “Indeed, biochemical data indicate that several parallel pathways link TNF-R1/TRAF2 to MKK7 and JNK.”
• Mitogen-Activated Protein Kinases and Reactive Oxygen Species: How Can ROS Activate MAPK Pathways? (2011, background): “A study has been shown that ASK-1-knockout mice exhibited lower levels of JNK and p38 activation in comparison to wild type after oxidant treatment [32].”
• Redox Regulation of Cell Survival (2008, neutral): “phosphorylation of JNK and JNK-induced cell death (297).”
• JNK Signaling in Apoptosis (2008, background): “Although studies with ASK / embryonic fibroblasts have indicated that ASK1 is not required for the transient activation of JNK, it is required for the persistent activation of JNK and apoptosis induced by TNF-a (Tobiume et al., 2001).”
• The Matricellular Protein CCN1/CYR61 Induces Fibroblast Senescence and Restricts Fibrosis in Cutaneous Wound Healing (2010, background): “ROS can activate stress-activated kinases such as MAPKs through activation of the redox-sensitive ASK1 (apoptosis signal-regulating kinase 1; ref”
• Understanding MAPK Signaling Pathways in Apoptosis (2020, background): “Thus, ask1−/− embryonic fibroblasts are resistant to H2O2-induced apoptosis and sustained activation of JNK and p38 MAPK is lost [93].”
• Oxidative Stress and Oxidative Damage in Carcinogenesis (2010, background): “The induction of AP-1 is mediated mainly by the c-Jun N-terminal kinase (JNK) and p38 MAP kinase cascades (Chang and Karin 2001).”
• An integrated view of oxidative stress in aging: basic mechanisms, functional effects, and pathological considerations. (2007, background): “A novel protein in the mitogen-activated-kinase-kinase-kinase family, known as apoptosis signal-regulating kinase 1 (ASK1), has recently been identified as a critical redox sensor in the MAPK pathway (83, 262, 268).”
• ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats. (2002, methodology): “Immunoblotting analysis has been described (Tobiume et al. 2001).”
• Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells (2006, background): “H 2 O 2 -induced activation of p38 MAPK is suppressed in MAP3k5 −/− cell”
• ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity (2005, background): “ASK1, which is encoded by Map3k5 , activates the MAP kinase kinase 4 (MKK4)-Jnk and MKK7-Jnk and MKK3-p38 and MKK6-p38 pathways and it is pivotal in cytokine- and stress-induced apoptosis in mammalian cell”
• Roles of CHOP/GADD153 in endoplasmic reticulum stress (2004, background): “MAPKKK ASK1, which is required for activation of JNK by Ire1 during ER stress, can also activate the p38 pathway.(19,55) ASK1 null cells are resistant to ER stress-induced apoptosis.”
• Cellular response to oxidative stress: Signaling for suicide and survival * (2002, background): “ASK1 deletion, which also eliminates JNK activation in response to hydrogen peroxide treatment, renders ASK1 / MEF resistant to apoptosis by the oxidant (Tobiume et al., 2001).”