Viruses and interferons.

By G. Sen. Annual Review of Microbiology, 2001

1,062 citations recorded by the source corpus.

Subfields: Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/beec67a233173d02728356f225c81ceae8310843

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In Immunology

1. Shizuo Akira
2. O. Takeuchi
3. M. Gale
4. Y. Loo
5. Mitsutoshi Yoneyama
6. Kui Li
7. T. Fujita
8. E. Latz

In Oncology

1. Shizuo Akira
2. M. Gale
3. Y. Loo
4. J. Hoofnagle
5. E. Wherry
6. J. Feld
7. Eileen M. Foy
8. O. Takeuchi

Citations in the corpus

• Evasion of intracellular host defence by hepatitis C virus (2005, background): “The host response is triggered when a pathogen-associated molecular pattern (PAMP) presented by the infecting virus is recognized and engaged by specific PAMP receptor factors expressed in the host cell, initiating signals that ultimately induce the expression of antiviral effector gene”
• Interferon signaling and treatment outcome in chronic hepatitis C (2008, background): “ISGencoded proteins establish a general antiviral state within the cell (9).”
• Regulating Intracellular Antiviral Defense and Permissiveness to Hepatitis C Virus RNA Replication through a Cellular RNA Helicase, RIG-I (2005, background): “Virus-induced production of IFN- and IFN- and the subsequent expression of IFN-stimulated genes (ISGs) are central to these antiviral defenses ( 22 ).”
• Commensal Bacteria Calibrate the Activation Threshold of Innate Antiviral Immunity (2012, background): “Induction of a type I IFN response is fundamental and critical for defense against the major ty of virus s (Sen, 2001).”
• Lambda Interferon (IFN-λ), a Type III IFN, Is Induced by Viruses and IFNs and Displays Potent Antiviral Activity against Select Virus Infections In Vivo (2006, background): “, blockage of viral entry into the cell, control of viral transcription, cleavage of RNA, and preventing translation (16, 31, 37).”
• Mechanism of action of interferon and ribavirin in treatment of hepatitis C (2005, background): “Mechanism of action of therapeutic IFN The type-1 IFNs include interferons-α, β, ω and λ, all of which play a crucial role in the innate antiviral immune respons”
• Human Cytomegalovirus Activates Inflammatory Cytokine Responses via CD14 and Toll-Like Receptor 2 (2003, background): “Viruses have long been known to activate innate immune responses characterized by the induction of inflammatory cytokines and a comprehensive set of ISGs (45, 53).”
• Shared and Unique Functions of the DExD/H-Box Helicases RIG-I, MDA5, and LGP2 in Antiviral Innate Immunity1 (2005, background): “Particularly, an increasing number of studies suggest that viruses encode numerous inhibitory proteins for the molecules of the innate antiviral loop (27).”