IL-17 Signaling: The Yin and the Yang

By Nilesh Amatya, A. Garg, S. Gaffen. Trends in immunology, 2017

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Interleukin (IL)-17 is the founding member of a novel family of inflammatory cytokines. While the pro-inflammatory properties of IL-17 are key to its host-protective capacity, unrestrained IL-17 signaling is associated with immunopathology, autoimmune disease and cancer progression. In this review, we discuss both the activators and the inhibitors of IL-17 signal transduction, and the physiological implications of these events. We highlight the surprisingly diverse means by which these regulators control expression of IL-17-dependent inflammatory genes, as well as the major target cells that respond to IL-17 signaling.

Subfields: Immunology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/4d2f816914b06220359df7ac49c7dc53685fb885