Vernalization-Mediated Epigenetic Silencing by a Long Intronic Noncoding RNA

By J. Heo, Sibum Sung. Science, 2011

1,131 citations recorded by the source corpus.

Subfields: Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/bd9edf3e1ffec9a07e9bdb593f4c882e9aa06f27

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Citations in the corpus

Regulation of flowering time: all roads lead to Rome (2011, background): “VRN1 and VRN2 were found to encode a DNA binding protein and a nuclear localized zinc finger protein with similarity to the polycomb group protein Su(Z)12 from Drosophila; this further supported the hypothesis that VRN1 and VRN2 maintaining the epigenetic repression of FLC. Sung and Amasino [96] ide”
Genotype-by-Environment Interaction and Plasticity: Exploring Genomic Responses of Plants to the Abiotic Environment (2013, background): “Expression of FT is repressed by Flowering Locus C (FLC), a transcription factor that itself is repressed by a transcriptional regulator Frigida (FRI) ( Johanson et al. 2000, Michaels & Amasino 1999) and through epigenetic mechanisms (Heo & Sung 2011).”
Genome regulation by long noncoding RNAs (2012, background): “In an analogous fashion, plants control the seasonal timing of flowering (a process termed vernalization) by a cold-inducible intronic lncRNA termed COLDAIR; COLDAIR recruits the PRC2 in cis to silence the flowering regulator gene FLC (82).”
On the classification of long non-coding RNAs (2013, background): “…with the following categories: 92 (1) signal: show cell type-specific expression and respond to diverse stimuli, such as Xist , 64 COLDAIR ; 62 (2) decoy: bind and titrate away a protein target, but does not transcription regulation can be sub-divided according to the mechanism of their…”
The multidimensional mechanisms of long noncoding RNA function (2017, background): “Indeed, since the early studies that demonstrated the central role of Xist in the process of X-chromosome inactivation [3, 4], a growing body of evidence has described a myriad of functions for lncRNAs in many cellular processes, such as gene imprinting [5], differentiation and development [6], anti”
Comprehending crystalline β-carotene accumulation by comparing engineered cell models and the natural carotenoid-rich system of citrus (2011, neutral): “About 10 ng of RNA was used for quantitative real-time PCR.”
An adaptive epigenetic memory in conifers with important implications for seed production (2012, neutral): “COLDAIR targets PRC2 to FLC (Swiezewski et al., 2009; Heo and Sung, 2011).”
Long Noncoding RNAs: Past, Present, and Future (2013, background): “One example that has been implicated in plant vernalization is COLDAIR, which is located in the first intron of the flowering repressor locus FLC (Heo and Sung 2011).”
Gene regulation by the act of long non-coding RNA transcription (2013, background): “In Arabidopsis thaliana, the COLDAIR lncRNA is initiated from an intron of the FLC pc gene and silences it by targeting repressive chromatin marks to the locus to control flowering time [28].”
Molecular mechanisms of long noncoding RNAs (2011, background): “In the plant Arabidopsis thaliana, winter cold triggers enrichment of trimethylated histone H3K27 at the chromatin of the floral repressor, FLOWERING LOCUS C (FLC), and results in epigenetically stable repression of FLC.”
Mechanisms and Functions of Long Non-Coding RNAs at Multiple Regulatory Levels (2019, background): “The lncRNA transcribed from FLC intron 1, consistent with the direction of FLC transcription, has been named COLD ASSISTED INTRONIC NONCODING RNA (COLDAIR) [22].”