Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project

By Ewan Birney, J. Stamatoyannopoulos, A. Dutta, Roderic Guigó, Thomas R. Gingeras, Elliott H. Margulies, Zhiping Weng, Michael Snyder, Emmanouil T. Dermitzakis, Robert E. Thurman and 300 more. Nature, 2007

5,374 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/8b9cff29b49f65aa8b4b765e09eb8d6daeeee984

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In Molecular Biology

1. Howard Y. Chang
2. John S. Mattick
3. David P. Bartel
4. Johannes Rinn
5. Manolis Kellis
6. Aviv Regev
7. Cole Trapnell
8. Eric S. Lander

Citations in the corpus

• The many pathways of RNA degradation. (2009, background): “However, over time these observations came to be largely discounted, until supported by deep sequence analyses (Birney et al., 2007; Han et al., 2007; Maeda et al., 2006).”
• Identifying a High Fraction of the Human Genome to be under Selective Constraint Using GERP++ (2010, methodology): “PolII binding regions were defined as 50 bp upstream and downstream of PolII binding ‘peaks’ as identified from ChIP-seq experiments performed by the ENCODE Consortium [3].”
• Transcription Factors Bind Thousands of Active and Inactive Regions in the Drosophila Blastoderm (2008, background): “Only a recent paper from the ENCODE Consortium [81] has seriously considered the possibility that a significant percent of in vivo binding may be nonfunctional, based on the lack of evolutionary constraint in bound sequences.”
• Roles, Functions, and Mechanisms of Long Non-coding RNAs in Cancer (2016, background): “lncRNAs are present in large numbers in genome [28,29].”