Transient expression of doublecortin during adult neurogenesis

By Jason Brown, S. Couillard-Després, C. Cooper-Kuhn, Jürgen Winkler, L. Aigner, H. Kuhn. The Journal of comparative neurology, 2003

1,567 citations recorded by the source corpus.

Subfields: Developmental Neuroscience, Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/b20493ab9868868bf17fbe93e4d1c95c1813d2d2

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Citations in the corpus

Granule cell dispersion is not accompanied by enhanced neurogenesis in temporal lobe epilepsy patients. (2007, background): “DCX is an established marker for newly generated neurons in the subgranular zone of the adult rodent and human dentate gyrus (Brown et al., 2003; Rao and Shetty, 2004; CouillardDespres et al., 2005; Jin et al., 2004).”
Delayed Development of Adult-Generated Granule Cells in Dentate Gyrus (2006, background): “Delayed development of adult-generated granule cells Although various immunohistochemical markers have been correlated with the postmitotic age of adult-generated granule cells (Seki, 2002; Brown et al., 2003), this approach does not allow direct correlation with cell function.”
Nuclear factor of activated T cells (NFATc4) is required for BDNF-dependent survival of adult-born neurons and spatial memory formation in the hippocampus (2012, background): “This observation is in agreement with the evidence that DCX and PSA-NCAM often are coexpressed in adult-born neurons during neurogenesis in the DG (19).”
Doublecortin expression levels in adult brain reflect neurogenesis (2005, methodology): “A recent report suggested that the number of DCX-expressing cells correlates with the level of cellular proliferation in the dentate gyrus (Brown et al., 2003b; Rao & Shetty, 2004), however, it remained unclear whether this correlation is maintained when levels of neurogenesis are modulated by…”
Epigenetic Modulation of Seizure-Induced Neurogenesis and Cognitive Decline (2007, background): “…proliferating progenitors (using Ki67 as a marker of cycling cells) (Gerdes et al., 1983; Kee et al., 2002) for their coexpression of DCX, a marker for dividing neuroblasts and immature neurons (Brown et al., 2003; Couillard-Despres et al., 2005; Jessberger et al., 2005) by confocal microscopy.”
Neuroprotective effects of estradiol in hippocampal neurons and glia of middle age mice. (2007, positive): “As demonstrated by us here and also by others (Brown et al., 2003; McDonald and Wojtowicz, 2005), the incidence of DCX+cells was markedly decreased in aging rats and MA mice.”
Adult neurogenesis modulates the hippocampus-dependent period of associative fear memory. (2009, background): “Notably, irradiation dramatically reduced the population of doublecortin+ (DCX+) cells in rat DG 1 day after irradiation (DCX is transiently expressed in 2 week-old-cells (Brown et al., 2003)) (Figure 1C).”
Maturation time of new granule cells in the dentate gyrus of adult macaque monkeys exceeds six months (2011, background): “Antidepressants generally take 3–5 wk to have clinical efficacy on depression in humans (22, 51), a period that coincides with the maturation of adult born neurons in the hippocampus of the adult rat (14, 16, 18).”
Reversible effect of X‐irradiation on proliferation, neurogenesis, and cell death in the dentate gyrus of adult mice (2007, neutral): “In adult rats, up to 60% of proliferating cells are positive for DCX (Brown et al., 2003).”
Mecp2 deficiency leads to delayed maturation and altered gene expression in hippocampal neurons. (2007, methodology): “This procedure was performed based on the published method (Brown et al., 2003).”
Disrupted-In-Schizophrenia 1 regulates integration of newly generated neurons in the adult brain. (2007, background): “Immunostaining of doublecortin (DCX; Figure 1C), an immature neuronal marker (Brown et al., 2003), revealed that 84.5 ± 9.5% of shRNA-C1/GFP+ cells and 89.3 ± 6.4% of shRNA-D1/GFP+ cells (n = 4 animals) became neurons at one week post injection (wpi).”
A Neurovascular Niche for Neurogenesis after Stroke (2006, background): “org as supplemental material) (Brown et al., 2003; Aguirre and Gallo, 2004; Kokovay et al., 2006), but are immunoreactive for other markers of CNS progenitor cells in this model, such as PSA-NCAM and musashi (Tsai et al.”
Visualization and genetic manipulation of adult neurogenesis using transgenic mice (2011, background): “DCX reporter mice emerged following studies that implicated DCX as a reliable marker for neurogenesis (Brown et al., 2003; Rao & Shetty, 2004; Song et al., 2005).”