Blimp-1 is required for the formation of immunoglobulin secreting plasma cells and pre-plasma memory B cells.

By Miriam Shapiro-Shelef, Kuo-I Lin, L. McHeyzer-Williams, J. Liao, M. McHeyzer-Williams, K. Calame. Immunity, 2003

890 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/bc3605716858b88f15379e3adfec50dbb13ddfa9

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Citations in the corpus

Generation of stable monoclonal antibody-producing BCR+ human memory B cells by genetic programming (2009, background): “Recent advances have provided insight into how multiple transcription factors, including B lymphocyte–induced maturation protein-1, X-box–binding protein-1 and Bcl-6 control development of germinal center B cells into terminally arrested, antibody-producing plasma cell”
The endoplasmic reticulum stress response in immunity and autoimmunity (2008, background): “B-lymphocyte-induced maturation protein 1 ( BLIMP1 ; also known as PRDM1) and interferon (IFN)-regulatory factor 4 ( IRF4 ) are two transcriptional regulators that are required for plasma-cell developmen”
The PR/SET Domain Zinc Finger Protein Prdm4 Regulates Gene Expression in Embryonic Stem Cells but Plays a Nonessential Role in the Developing Mouse Embryo (2013, background): “disrupt Prdm1 functional activity in vivo (8, 59).”
Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination (2006, background): “Although Blimp-1 has been shown to be required for the generation of plasma cell”
Blimp-1 promotes terminal differentiation of virus-specific CD8 T cells and represses the acquisition of central memory T cell properties (2009, background): “In this study, we asked whether Blimp-1, a transcriptional repressor known to regulate the terminal differentiation of diverse cell types, plays a functional role in regulating effector and memory CD8 T cellfate decisions (Horsley et al., 2006; Magnusdottir et al., 2007; Ohinata et al., 2005; Shapir”
Competence and competition: the challenge of becoming a long-lived plasma cell (2006, background): “BLIMP1 increases the expression of the transcription factor XBP1, which in its activated form (generated by differential splicing) induces the unfolded-protein response in plasma cells and therefore controls the ER stress that is caused by the massive production of antibod”
IL-21 Induces Differentiation of Human Naive and Memory B Cells into Antibody-Secreting Plasma Cells1 (2005, background): “BLIMP-1 is a transcriptional repressor that is necessary/sufficient for plasma cell differentiation in the mouse, and in human B cell lines (33, 37, 38).”
Germinal centres: role in B-cell physiology and malignancy (2008, background): “Prdm1 encodes B-lymphocyte-induced maturation protein 1 ( BLIMP1 ), a transcriptional repressor that is crucially required for plasma-cell developmen”
Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers (2013, background): “PRDM1/BLIMP-1 encodes a transcription factor that is considered a master regulator of plasma cell development and is required for the formation of plasma cell tumors in a mouse model (Shapiro-Shelef et al., 2003; Turner et al., 1994).”