Competence and competition: the challenge of becoming a long-lived plasma cell

By A. Radbruch, G. Muehlinghaus, E. Luger, A. Inamine, Kenneth G. C. Smith, T. Dörner, F. Hiepe. Nature reviews. Immunology, 2006

1,103 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Human B1 cells in umbilical cord and adult peripheral blood express the novel phenotype CD20+CD27+CD43+CD70− (2011, background): “In identifying human B1 cells we focused on CD20+ B cells to avoid the few circulating terminally differentiating (CD20) plasma cells that have been reported in peripheral blood samples and that can secrete Ig (Radbruch et al., 2006).”
Fcγ receptors as regulators of immune responses (2008, background): “Plasma cells reside predominantly in niches in the bone marrow, where they have to receive survival signals from stromal cell”
From Vaccines to Memory and Back (2010, positive): “…are present in the bone marrow and secrete antibodies in an antigen-independent fashion thus maintaining constant levels in serum and body fluids (Radbruch et al., 2006); recall responses are mediated by memory B cells that rapidly proliferate and differentiate in response to antigenic…”
IgE in allergy and asthma today (2008, result): “; this is consistent with the hypothesis that inflamed tissues, as well as the bone marrow, constitute a survival niche for antibody-secreting plasma cell”