Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination

By U. Klein, S. Casola, G. Cattoretti, Qiong Shen, M. Lia, Tongwei Mo, T. Ludwig, K. Rajewsky, R. Dalla-Favera. Nature Immunology, 2006

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Subfields: Immunology

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The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection (2010, background): “Irf4 has been shown to be involved in T H 2 cell polarization as well as in plasma cell differentiation and class-switch recombination in B cell”
The endoplasmic reticulum stress response in immunity and autoimmunity (2008, background): “B-lymphocyte-induced maturation protein 1 ( BLIMP1 ; also known as PRDM1) and interferon (IFN)-regulatory factor 4 ( IRF4 ) are two transcriptional regulators that are required for plasma-cell developmen”
IRF4 Transcription Factor-Dependent CD11b+ Dendritic Cells in Human and Mouse Control Mucosal IL-17 Cytokine Responses (2013, background): “In these mice (Itgax-cre Irf4), expression of the Cre recombinase leads to excision of both exons, preventing transcription of the Irf4 gene only in CD11c cells and concomitantly enabling GFP expression in recombined CD11c cells, allowing the tracking of Irf4-deficient cells (Klein et al., 2006).”
Transcriptional control of adipose lipid handling by IRF4 (2011, positive): “Generation of FI4KO Mice Irf4 mice were generated as described previously (Klein et al., 2006).”