Mitogen-Activated Protein Kinase Pathways Mediated by ERK, JNK, and p38 Protein Kinases

By G. Johnson, R. Lapadat. Science, 2002

4,418 citations recorded by the source corpus.

Subfields: Molecular Biology, Organic Chemistry

View Paper: https://www.semanticscholar.org/paper/bbe7b8dbe925d5a2d147840da7010e169abf1339

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Citations in the corpus

Cisplatin in cancer therapy: molecular mechanisms of action (2014, positive): “Mitogen activated protein kinases are a family of structurally related serine/threonine protein kinases that coordinate various extra cellular signals to regulate cell growth and survival (Chang and Karin, 2001;Johnson and Lapadat, 2002;Marshall, 1995).”
Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention (2019, background): “Each one is separately regulated within individual cells (184) [for an overview of kinase inhibitors see (183)].”
Differential regulation and properties of MAPKs (2007, background): “Activation of ERK1/2 is involved in many cellular responses such as cell motility, proliferation, differentiation and survival (Lewis et al., 1998; Chen et al., 2001; Johnson and Lapadat, 2002; Yoon and Seger, 2006).”
Mechanisms underlying differential responses to FGF signaling. (2005, background): “This family shares many structural similarities and includes the ERK1/2 kinases which are generally considered responsible for the mitogenic response, while the p38 and JNK MAP kinases are usually associated with inflammatory or stress-responses [43].”
Structural insights into the recruitment of SMRT by the corepressor SHARP under phosphorylative regulation. (2013, background): “and regulated by their own specific kinases in signal transduction pathways (Darnell et al., 1994; Johnson and Lapadat, 2002; Kretzschmar and Massagué, 1998).”
Molecular Mechanisms of Treg-Mediated T Cell Suppression (2012, background): “MAPKs promote expression, phosphorylation, and activation of Fos and Jun, which together comprise the AP-1 transcription factor (Johnson and Lapadat, 2002).”
Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis (2010, background): “ERK has a predominant role in regulating mitotic responses and cell growth and differentiation while p38 and JNK are the main responders to various stress signals, including inflammation, heat, and genotoxic events (116).”
MAP kinase and pain (2008, background): “ERK5 is a new but less-known member of the family (Johnson and Lapadat, 2002).”
AP-1: a double-edged sword in tumorigenesis (2003, background): “p38 is activated by many conditions that are known to suppress tumour growt”