Evidence that stem cells reside in the adult Drosophila midgut epithelium

By C. Micchelli, Norbert Perrimon. Nature, 2006

1,146 citations recorded by the source corpus.

Subfields: Aging, Cellular and Molecular Neuroscience, Immunology

View Paper: https://www.semanticscholar.org/paper/bb784aa8f1949aa4ffee5546ad0c5050c8a31245

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Aging

1. Juergen A. Knoblich
2. N. Broderick
3. D. Scadden
4. B. Lemaître
5. Nicolas Buchon

In Cellular and Molecular Neuroscience

1. Juergen A. Knoblich
2. D. L. Jones
3. N. Broderick
4. A. Wagers
5. U. Pandey
6. D. Scadden
7. Sveta Chakrabarti
8. B. Lemaître

In Immunology

1. Nicolas Buchon
2. Juergen A. Knoblich
3. D. L. Jones
4. Bruce Edgar
5. Parthive H. Patel
6. N. Broderick
7. D. McEwen
8. A. Wagers

Citations in the corpus

• Human Disease Models in Drosophila melanogaster and the Role of the Fly in Therapeutic Drug Discovery (2011, background): “…high throughput screening system relies upon flies with gain of function raf or a dominant negative allele of Notch, that each exhibit abnormal cell growth of midgut epithelium as a model for asymmetric stem cell division related cancers (Micchelli and Perrimon, 2006; Januschke and Gonzalez, 2008).”
• No place like home: anatomy and function of the stem cell niche (2008, background): “melanogaster , which maintain the intestinal epithelium and generate both polyploid enterocytes as well as hormone-producing enteroendocrine cell”
• Cytokine/Jak/Stat signaling mediates regeneration and homeostasis in the Drosophila midgut (2009, methodology): “The Drosophila adult midgut is maintained by ISCs that selfrenew and also produce the two principal differentiated cell types of the intestinal epithelium: absorptive enterocytes (ECs) and secretory enteroendocrine (EE) cells (Micchelli and Perrimon, 2006; Ohlstein and Spradling, 2006).”
• Mechanisms of asymmetric stem cell division. (2008, background): “The striking discovery of stem cell lineages in the adult Drosophila gut (Micchelli and Perrimon, 2006; Ohlstein and Spradling, 2006), malpighian tubules (Singh et al.”
• Invasive and indigenous microbiota impact intestinal stem cell activity through multiple pathways in Drosophila. (2009, background): “In basal conditions, the adult gut epithelium is renewed in ;1–2 wk (Micchelli and Perrimon 2006).”
• The stem-cell niche as an entity of action (2006, background): “Two reports have demonstrated that the posterior mid-gut populations of cells in Drosophila have the capacity to produce daughter cells of at least two types: enterocytes and enteroendocrine cell”
• Basal cells as stem cells of the mouse trachea and human airway epithelium (2009, background): “This concept has been proposed for the Drosophila midgut, where varying levels of Notch ligand in the intestinal stem cells regulates the fates of their progeny (25, 26).”
• Drosophila intestinal response to bacterial infection: activation of host defense and stem cell proliferation. (2009, methodology): “The adult Drosophila midgut also contains multipotent ISCs, and it was suggested that ISCs respond to signals emitted by surrounding epithelial cells to produce appropriate daughter cells (Micchelli and Perrimon, 2006; Ohlstein and Spradling, 2006).”