Basal cells as stem cells of the mouse trachea and human airway epithelium

By J. Rock, M. Onaitis, E. Rawlins, Yun Lu, C. Clark, Yan Xue, S. Randell, B. Hogan. Proceedings of the National Academy of Sciences of the United States of America, 2009

1,483 citations recorded by the source corpus.

Subfields: Molecular Biology, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/69390b31f09a5d3002cf7b48c2a4970f4b493a61

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Citations in the corpus

Airway basal stem cells: a perspective on their roles in epithelial homeostasis and remodeling (2010, methodology): “Selected markers common to mouse and human BCs Gene symbol (protein) Reference for expression in mouse Reference for expression in human Trp63 Rock et al., 2009 Araya et al., 2007 Snai2 Parent et al., 2004; Rock et al., 2009 J.R.R. and B.L.M.H., unpublished data Ngfr Rock et al., 2009 Rock et al.,…”
In vitro generation of human pluripotent stem cell derived lung organoids (2015, background): “…cultures (>2 months) where the P63+ cells are spatially arranged along the basal side of the epithelial tube-like structures, adjacent to SMA+ mesenchyme, similar to human bronchi and bronchioles (Figure 4B) (Boers et al., 1998; Nakajima et al., 1998; Evans et al., 2001; Rock et al., 2009).”
Long‐term expanding human airway organoids for disease modeling (2019, positive): “No mature club, neuroendocrine, or mucus-producing cells were observed (Rock et al , 2009).”
Type 2 alveolar cells are stem cells in adult lung. (2013, neutral): “Sorted cells were resuspended in MTEC/Plus (48), and mixed with 1:1 growth factor–reduced Matrigel (BD Biosciences); 90 μ l was placed in a 24-well 0.4-μ m Transwell insert (Falcon).”
Preparing for the First Breath: Genetic and Cellular Mechanisms in Lung Development (2010, background): “There is good evidence that in the mouse trachea, the basal cells are long term progenitor/stem cells that give rise to Clara and ciliated cells both in steady state and after epithelial injury (Rock et al., 2009).”
Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis (2019, background): “Investigators identified a population of basal cells in the airway that expand after tracheal injury (40).”
Cilia and Mucociliary Clearance (2017, background): “These multipotent cells will give rise to the major cell types of the conducting airways, including basal stem cells (Rock et al. 2009), neurosecretory cells (Kultschitsky or Kcells) (Becker and Silva 1981), ciliated cells, club cells, serous cells, goblet cells, intermediate cells, and brush cells ”