A novel inflammation‐related mouse colon carcinogenesis model induced by azoxymethane and dextran sodium sulfate

By Takuji Tanaka, H. Kohno, Rikako Suzuki, Yasuhiro Yamada, S. Sugie, H. Mori. Cancer Science, 2003

750 citations recorded by the source corpus.

Subfields: Cancer Research, Pharmacology, Surgery

View Paper: https://www.semanticscholar.org/paper/bb2ba1657b355b80ed60f972a1d0b73c2faa9675

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. S. Rose‐John
2. R. Flavell
3. F. Greten
4. H. Hermeking
5. M. Karin

In Pharmacology

1. R. Flavell
2. Markus F. Neurath

In Surgery

1. S. Rose‐John
2. Wenjun Ouyang
3. Markus F. Neurath

Citations in the corpus

• Wild Mouse Gut Microbiota Promotes Host Fitness and Improves Disease Resistance (2017, positive): “This results in chronic inflammation and progression to dysplasia and adenocarcinoma, thereby creating a robust model of colitis-associated colorectal cancer (Tanaka et al., 2003).”
• TGF-β Suppresses Tumor Progression in Colon Cancer by Inhibition of IL-6 trans-Signaling (2004, background): “Taken together, our data provide Results novel insights into TGF- signaling in colorectal canIn order to investigate the functional role of TGF- sigcer and suggest novel therapeutic approaches for naling in colon carcinogenesis, we used a previously colorectal cancer based on inhibition of TGF- -dep”
• IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine (2012, positive): “We therefore generated Il22bp −/− mice (Supplemental Figure 2) and used a colitis-associated colon cancer model, which resembles the pathology of human colitis-associated neoplasia 17,18 (Supplemental Figure 3), in order to analyze the role of IL-22BP during tumorigenesis in the colon.”
• IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis. (2014, background): “Repeated DSS administration causes chronic inflammation, which greatly enhances the incidence of AOM-induced tumors (35).”
• The Gut Microbiome Modulates Colon Tumorigenesis (2013, methodology): “This was repeated twice for a total of 3 rounds of DSS (26, 27).”
• Chemically induced mouse models of intestinal inflammation (2007, background): “, 7 days DSS, 14 days water) results in chronic colitis and if combined with a single initial dose of the genotoxic colon carcinogen azoxymethane (AOM), in inflammation-associated colorectal cance”
• Chronic Inflammation and Cytokines in the Tumor Microenvironment (2014, background): “AOM is a mutagenic agent favoring mutation of the β-catenin protooncogene, inducing localization to the nucleus and increasing iNOS and cyclooxygenase (COX-2) expression [190, 191].”
• Novel insights into Notum and glypicans regulation in colorectal cancer (2015, background): “Although the model does not progress to metastasis, as shown by studies extending until 20–30 weeks from tumor induction, it mimics quite well many of the steps found in human sporadic CRC progression [8].”
• An inducible mouse model of colon carcinogenesis for the analysis of sporadic and inflammation-driven tumor progression (2007, background): “A two-stage colon tumor model that mimics colitis-driven tumor development has been describe”