Chemically induced mouse models of intestinal inflammation

By S. Wirtz, C. Neufert, B. Weigmann, Markus F. Neurath. Nature Protocols, 2007

1,604 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/21afc836b56d12cf9d18263373883f0c8a1c4b30

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In Immunology

Citations in the corpus

How informative is the mouse for human gut microbiota research? (2015, background): “The latter include biological agents, such as infective pathogens (for example, Helicobacter hepaticus and Citrobacter rodentium), or chemicals, such as dextran sulfate sodium (DSS) and 2,4,6-trinitrobenzene sulfonic acid (TNBS), which cause the initial damage that leads to chronic intestinal inflam”
Exogenous stimuli maintain intraepithelial lymphocytes via aryl hydrocarbon receptor activation. (2011, positive): “…of AhR deficiency for intestinal physiology, we employed dextran sodium sulfate (DSS)-induced colitis, a model of chemically induced epithelial damage and inflammation that is exacerbated by bacterial dissemination, especially in the absence of IELs (Ismail et al., 2009; Wirtz et al., 2007).”
Outer Membrane Vesicles of a Human Commensal Mediate Immune Regulation and Disease Protection (2012, methodology): “, 2008; Round and Mazmanian, 2010), including intestinal inflammation induced by 2,4,6-trinitrobenzene sulfonic acid (TNBS) (Wirtz et al., 2007).”
Novel insights into Notum and glypicans regulation in colorectal cancer (2015, background): “In that case, the inflammation becomes chronic and non-resolved [24], as seen in human IBD-related CRC where chronic inflammation always precedes and is directly linked to tumor formation [25, 26].”
Dextran Sodium Sulphate Colitis Mouse Model: Traps and Tricks (2012, background): “Inflammatory bowel disease (IBD) is a complex multifactorial disease of unknown etiology.”
The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis (2010, neutral): “Scoring for stool consistency and occult blood was done as described previously (Wirtz et al., 2007).”
Orally delivered thioketal-nanoparticles loaded with TNFα-siRNA target inflammation and inhibit gene expression in the intestines (2010, methodology): “Intestinal inflammation was induced in female C57BL/6 mice by replacing their drinking water on day zero with a 3% solution of DSS (ref”
Computational repositioning of the anticonvulsant topiramate for inflammatory bowel disease (2011, methodology): “Experimental evaluation of topiramate in a rodent TNBS model of IBD Experimental validation of treatment efficacy was performed with a TNBS (also known as picryl sulfonic acid)–induced rodent model of IBD (20, 21).”