An inducible mouse model of colon carcinogenesis for the analysis of sporadic and inflammation-driven tumor progression

By C. Neufert, C. Becker, Markus F. Neurath. Nature Protocols, 2007

694 citations recorded by the source corpus.

Subfields: Biotechnology, Oncology, Psychiatry and Mental health

View Paper: https://www.semanticscholar.org/paper/a2d1bd7bd7269f125d6a92ccd2328406745dae7a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biotechnology

1. H. Hermeking

In Oncology

1. F. Greten
2. H. Hermeking
3. Markus F. Neurath
4. M. Karin

In Psychiatry and Mental health

1. F. Greten

Citations in the corpus

• IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis. (2014, methodology): “In order to analyze the relevance of an IL-6R/ STAT3/miR-34a feedback loop in an autochthonous colorectal tumor model we employed the well-established azoxymethane/ dextran sodium sulfate (AOM/DSS) model (33), which closely recapitulates human colitis-associated cancer (CAC).”
• Novel insights into Notum and glypicans regulation in colorectal cancer (2015, background): “Conversely, tumors generated by our “two step” AOM/DSS treatment accurately recapitulate the pathogenesis observed in human sporadic noninflammatory CRC [28].”
• IL-6 signaling in autoimmunity, chronic inflammation and inflammation-associated cancer. (2011, background): “In a murine model of colitis-associated colon cancer driven by AOM/DSS, elevated levels of IL-6 and sIL-6R were noted [99–101].”