Calcium transients in astrocyte endfeet cause cerebrovascular constrictions

By S. Mulligan, B. MacVicar. Nature, 2004

909 citations recorded by the source corpus.

Subfields: Biochemistry, Neurology, Physiology

View Paper: https://www.semanticscholar.org/paper/b9cb107df7b07c436b7f10c25dfa2265334e5b3c

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Citations in the corpus

Astrocyte control of synaptic transmission and neurovascular coupling. (2006, methodology): “The results reported by Mulligan and MacVicar’s study (145) are in conflict with those reported by Zonta et al. (242) in which Ca2 elevations in astrocyte endfeet were observed to trigger dilation of cerebral arterioles.”
Glial and neuronal control of brain blood flow (2010, positive): “In brain slices and in the isolated retina rises in [Ca 2+ ] i in astrocytes can also constrict vessel”
Astrocyte-mediated control of cerebral blood flow (2006, background): “In contrast, a subsequent study that targeted astrocytes by Ca 2+ photolysis found that astrocytic Ca 2+ signaling is associated with cerebrovascular constriction mediated by a cytochrome P-450 metabolite, 20-hydroxy-(5 Z ,8 Z ,11 Z ,14 Z )-eicosatetraenoic acid (20-HETE”
Astroglial networks: a step further in neuroglial and gliovascular interactions (2010, background): “Indeed, a local [Ca 2+ ] i increase in a single perivascular digit spreads throughout the entire process of the astrocyte, including the endfoot, and then propagates to adjacent endfee”
Neurovascular coupling in the normal brain and in hypertension, stroke, and Alzheimer disease. (2006, background): “In contrast, Mulligan and MacVicar (52) demonstrated that release of caged Ca(2) in hippocampal astrocytes produces vasoconstriction, a response mediated by the cytochrome p450 metabolites 20-HETEs.”
Pathophysiology and Therapeutic Potential of Purinergic Signaling (2006, background): “…transmission and plasticity , glial cell differentiation, intercellular communication between glia, and myelination (Fields and Stevens, 2000; Burnstock, 2003b; Newman, 2003; Pascual and Haydon, 2003; Bowser and Khakh, 2004; Mulligan and MacVicar, 2004; Davalos et al., 2005; Köles et al., 2005).”
Perivascular nerves and the regulation of cerebrovascular tone. (2006, background): “2), a resurgence of interest in the regulation of microvascular tone has occurred (4, 13, 23, 27, 36).”
Regulation of retinal blood flow in health and disease. (2008, background): “, 1993), suggesting that these endfeet are engaged in signaling processes of blood flow regulation (Simard et al., 2003; Zonta et al., 2003; Mulligan and MacVicar, 2004; Peppiatt and Attwell, 2004) .”
Astrocyte dysfunction in neurological disorders: a molecular perspective (2006, background): “Rapid forms of neuron–glia interactions might also be involved in the regulation of local blood flow, as shown in cortical brain slices; neuronal stimulation led to glutamate release, activation of mGluRs in astrocytes and regulation of the tone of the vessels that are contacted by the stimulated as”
Cellular and physiological mechanisms underlying blood flow regulation in the retina choroid in health disease (2012, neutral): “In brain slice experiments, astrocyte stimulation can also result in vasoconstrictionmediated by production of 20-HETE (Mulligan and MacVicar, 2004), suggesting that glial cells can regulate blood flow,”
Astrocyte reactivity and reactive astrogliosis: costs and benefits. (2014, background): “Astrocytes were shown to control formation, maintenance, function, and removal of neuronal synapses (45, 68, 168, 228, 237, 238); help to control blood flow (104, 120, 153, 207, 276); and together with pericytes regulate the bloodbrain barrier (1, 11, 17, 133).”
The role of spreading depression, spreading depolarization and spreading ischemia in neurological disease (2011, background): “In addition, elevated basal potassium may cause increased intracellular calcium storage in astrocytes and vascular smooth muscle cells, which may further enhance the vasoconstrictor response when calcium is released from intracellular stores during spreading depolarizatio”
Purification and characterization of progenitor and mature human astrocytes reveals transcriptional and functional differences with mouse (2015, neutral): “, 1966), regulation of blood flow (Attwell et al., 2010; Mulligan and MacVicar, 2004; Zonta et al., 2003), and providing energy substrates for neurons (Pellerin and Magistretti, 1994).”