Glial and neuronal control of brain blood flow

By David Attwell, A. Buchan, S. Charpak, M. Lauritzen, B. MacVicar, E. A. Newman. Nature, 2010

2,393 citations recorded by the source corpus.

Blood flow in the brain is regulated by neurons and astrocytes. Knowledge of how these cells control blood flow is crucial for understanding how neural computation is powered, for interpreting functional imaging scans of brains, and for developing treatments for neurological disorders. It is now recognized that neurotransmitter-mediated signalling has a key role in regulating cerebral blood flow, that much of this control is mediated by astrocytes, that oxygen modulates blood flow regulation, and that blood flow may be controlled by capillaries as well as by arterioles. These conceptual shifts in our understanding of cerebral blood flow control have important implications for the development of new therapeutic approaches.

Subfields: Biochemistry, Neurology, Physiology

View Paper: https://www.semanticscholar.org/paper/4b0288f32a53094b5386643bbea56cb3803941bc

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Citations in the corpus

Physiology of Astroglia. (2018, neutral): “Coupling of neuronal activity with local circulation is controlled by multiple mechanisms; neurons, for example, are known to release vasoactive agents such as NO or prostaglandins, and brain vasculature is richly innervated by neuronal projections that exocytose vasoactive neurotransmitters includi”
The blood-brain barrier. (2015, background): “This neurovascular coupling enables astrocytes to relay signals that regulate blood flow in response to neuronal activity (Attwell et al. 2010; Gordon et al. 2011).”
Purification and characterization of progenitor and mature human astrocytes reveals transcriptional and functional differences with mouse (2015, neutral): “, 1966), regulation of blood flow (Attwell et al., 2010; Mulligan and MacVicar, 2004; Zonta et al., 2003), and providing energy substrates for neurons (Pellerin and Magistretti, 1994).”
The many faces of insulin-like peptide signalling in the brain (2012, background): “This mechanism of neurotrophic coupling, by which circulating IGF1 enters into the brain 'on demand' to provide localized support to active brain regions, occurs in parallel with the process of neurovascular coupling , with which it shares various mediator”
Cellular and physiological mechanisms underlying blood flow regulation in the retina choroid in health disease (2012, neutral): “In addition, recent work in both the brain and the retina indicate that arachidonic acid (AA) metabolites, produced by glial cells or as a consequence of glial cell activity, can also elicit vasodilation and increased blood flow; for review see Attwell et al. (2010).”
The blood-brain barrier: an engineering perspective (2013, background): “Pericytes wrap around microvessels and capillaries in the brain (Sims, 1986; Fisher, 2009; Attwell et al., 2010; Krueger and Bechmann, 2010; Dalkara et al., 2011; Winkler et al., 2011) and communicate with endothelial cells, astrocytes, and neurons in the neurovascular unit (Bonkowski et al., 2011).”
Multi-sensory gamma stimulation ameliorates Alzheimer’s-associated pathology and improves cognition. (2019, background): “Astrocytes are known to be intermediaries between neuronal activity and vasculature (Attwell et al., 2010; Filosa and Iddings, 2013).”
Ongoing Cortical Activity at Rest: Criticality, Multistability, and Ghost Attractors (2012, methodology): “We also tested simulations in which the activity zi is given by the glutamate turnover (Logothetis et al., 2001; Attwell et al., 2010) and obtained equivalent results, since the synaptic activity typically strongly correlates with the spiking activity in our network.”