Astrocyte-mediated control of cerebral blood flow

By T. Takano, G. Tian, Weiguo Peng, Nanhong Lou, W. Libionka, Xiaoning Han, Maiken Nedergaard. Nature Neuroscience, 2006

1,124 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Neurology

View Paper: https://www.semanticscholar.org/paper/d4be6b880a0aa4b0f2679cb494d0aa62c09eb5d7

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. Berislav Zlokovic
2. Philip Haydon
3. B. Barres
4. Giorgio Carmignoto
5. Jean Daunizeau
6. Klaas E. Stephan
7. E. A. Newman
8. Olivier David

In Neurology

1. Berislav Zlokovic
2. B. Barres
3. Philip Haydon
4. Giorgio Carmignoto
5. E. A. Newman
6. Ole Petter Ottersen
7. Frank Tong
8. Klaas E. Stephan

Citations in the corpus

• Astrocytes and disease: a neurodevelopmental perspective. (2012, background): “It is known that in this context, astrocytes play an important role in the regulation of cerebral blood flow (Takano et al. 2006; Attwell et al. 2010) as well as in regulating BBB permeability from the bloodstream into the brain parenchyma.”
• The perivascular astroglial sheath provides a complete covering of the brain microvessels: An electron microscopic 3D reconstruction (2010, background): “Importantly, calcium transients in astrocyte endfeet may be involved in the regulation of GLIA blood flow (Mulligan and MacVicar, 2004; Scemes et al., 1998; Takano et al., 2006; Zonta et al., 2003).”
• Astrocyte dysfunction in neurological disorders: a molecular perspective (2006, background): “Rapid forms of neuron–glia interactions might also be involved in the regulation of local blood flow, as shown in cortical brain slices; neuronal stimulation led to glutamate release, activation of mGluRs in astrocytes and regulation of the tone of the vessels that are contacted by the stimulated as”
• Astrocyte control of synaptic transmission and neurovascular coupling. (2006, background): “It should be noted in this in vivo study (204), as well as in Mulligan and MacVicar’s brain slice investigation (145), that a membrane-permeant EDTA-based caged compound was used for the photolytic control of internal Ca(2) .”
• Energy Metabolism in Astrocytes: High Rate of Oxidative Metabolism and Spatiotemporal Dependence on Glycolysis/Glycogenolysis (2007, background): “Endfeet surround precapillary arterioles (Wolff and Chao, 2004) and participate in Ca 2 + -mediated blood flow control by synthesis and release of compounds that regulate vascular diameter (Takano et al, 2006).”
• Neural bases of binocular rivalry. (2006, background): “If BOLD activity is indeed driven primarily by non-spiking, synaptic activity[ 78 ], then might the rivalry-related BOLD responses found in the”
• Glial Cells Dilate and Constrict Blood Vessels: A Mechanism of Neurovascular Coupling (2006, background): “Zonta et al. (2003) and Takano et al. (2006) showed that Ca 2ϩ increases in glial cells result in vasodilation mediated by production of cyclooxygenase (COX) metabolites.”