Astrocyte dysfunction in neurological disorders: a molecular perspective

By Gerald Seifert, K. Schilling, C. Steinhäuser. Nature Reviews Neuroscience, 2006

804 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience, Neurology

View Paper: https://www.semanticscholar.org/paper/2e584b329dd5e5137c6d527ce54913f564fb2b96

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. M. Sofroniew
2. M. Pekny
3. M. Pekna
4. E. Hol
5. H. Vinters
6. J. Burda

In Developmental Neuroscience

1. M. Sofroniew
2. M. Pekny
3. M. Pekna
4. E. Hol
5. H. Vinters
6. J. Burda
7. Xandra Pereiro

In Neurology

1. M. Pekny
2. M. Sofroniew
3. M. Pekna
4. E. Hol
5. H. Vinters
6. J. Burda
7. Xandra Pereiro

Citations in the corpus

• Astrocyte reactivity and reactive astrogliosis: costs and benefits. (2014, background): “The concept of reactive astrogliosis and its molecular and cellular definition is still incomplete, and we are only starting to understand its multifaceted functions in disease pathogenesis and in the process of recovery from CNS injuries (17, 34, 52, 146, 210, 221) (FIGURE 1).”
• Astrocytes: biology and pathology (2009, background): “Astrocyte processes at synapses also play essential roles in transmitter homeostasis by expressing high levels of transporters for neurotransmitters such as glutamate, GABA, and glycine that serve to clear the neurotransmitters from the synaptic space [205, 212].”
• Radiation-induced brain injury: A review (2012, background): “In response to injury, astrocytes undergo proliferation, exhibit hypertrophic nuclei/cell bodies, and show increased expression of glial fibrillary acidic protein (GFAP; Seifert et al., 2006; Yuan et al., 2006; Seth and Koul, 2008; Wilson et al., 2009; Zhou et al., 2011).”
• The biphasic function of microglia in ischemic stroke (2017, neutral): “They are able to sense the changes of brain environment and play an important role in various pathological conditions including ischemic stroke (Hanisch and Kettenmann, 2007; Ransohoff and Brown, 2012; Seifert et al., 2006; Tremblay et al., 2011).”
• Glial fibrillary acidic protein (GFAP) and the astrocyte intermediate filament system in diseases of the central nervous system. (2015, background): “affects both the disease progression and the recovery process [20,21 ,22].”
• The Impact of Astrocytic Gap Junctional Coupling on Potassium Buffering in the Hippocampus (2006, background): “If K regulation fails, pathological events such as spreading depression, anoxic depolarization, and epileptiform activity may be initiated (Somjen, 2001; Seifert et al., 2006).”