Relation of CD4+CD25+ regulatory T-cell suppression of allergen-driven T-cell activation to atopic status and expression of allergic disease.

By E. Ling, T. Smith, X. Nguyen, Carol Pridgeon, M. Dallman, J. Arbery, V. A. Carr, D. S. Robinson. The Lancet, 2004

789 citations recorded by the source corpus.

Subfields: Immunology, Immunology and Allergy, Physiology

View Paper: https://www.semanticscholar.org/paper/b9c2406ffaa2c8c57b2cf48810ed6ecf8c2e6e23

How researchers see this paper

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In Immunology

1. A. O’Garra
2. C. Hawrylowicz
3. Matthew D Taylor
4. Rick M. Maizels
5. M. Wilson
6. J. Lamb
7. A. Balic
8. F. Barrat

In Physiology

1. Rick M. Maizels
2. M. Wilson

Citations in the corpus

• Probiotics and prebiotic galacto-oligosaccharides in the prevention of allergic diseases: a randomized, double-blind, placebo-controlled trial. (2007, positive): “Probiotic strains that stimulate the expression of regulatory cytokines have effectively prevented or alleviated eczema.(7,8,35) Interestingly, in infants with eczema, the same combination of probiotic bacteria as used in this study induced the secretion of IL-10.”
• Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells (2006, background): “Although the best evidence for their importance comes from mouse models, an increasing number of reports have outlined disturbances in T reg cell numbers and/or function in patients with a wide variety of autoimmune (2–8) and allergic diseases (9, 10), in addition to the severe IPEX (immune dysregul”
• Suppression of allergic airway inflammation by helminth-induced regulatory T cells (2005, positive): “The possibility that T reg cells inhibit allergic disease has received growing support from both animal (13, 56) and human (14, 15, 57) studies.”
• Reversing the defective induction of IL-10-secreting regulatory T cells in glucocorticoid-resistant asthma patients. (2005, background): “CD4+CD25+ Tregs suppress allergen-induced proliferation and Th2 cytokine production by peripheral CD4+ T cells independently of IL-10 secretion (35).”
• Potential role of interleukin-10-secreting regulatory T cells in allergy and asthma (2005, neutral): “The study by Ling et al.(53) also showed that stimulation with allergen of CD4CD25 T cells from normal healthy individuals led to a markedly AIRWAY HYPER-”