Reversing the defective induction of IL-10-secreting regulatory T cells in glucocorticoid-resistant asthma patients.
By E. Xystrakis, S. Kusumakar, S. Boswell, E. Peek, Z. Urry, D. Richards, T. Adikibi, Carol Pridgeon, M. Dallman, T. Loke and 7 more. Journal of Clinical Investigation, 2005
622 citations recorded by the source corpus.
Subfields: Immunology, Physiology
View Paper: https://www.semanticscholar.org/paper/5df416f5545694e5f14641953a3a7ee4d7dc1c44
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In Immunology
In Physiology
Citations in the corpus
- Serum vitamin D levels and markers of severity of childhood asthma in Costa Rica. (2009, background): “For example, Xystrakis and colleagues have shown that vitamin D restores the capability of regulatory T cells from steroid-resistant patients with asthma to secrete IL-10 (a potent antiinflammatory cytokine) in response to steroids (8).”
- Corticosteroid resistance in patients with asthma and chronic obstructive pulmonary disease. (2013, background): “Inpatientswith steroid-resistant asthma, there appears to be a failure ofTreg cells to secrete IL-10, but this is restored by 25-hydroxy vitamin D3 (calcitriol), in vitro.(76,77) Numbers of TH17 cells, which secrete IL-17 and related cytokines, appear to be increased in patients with severe asthma a”
- Maternal intake of vitamin D during pregnancy and risk of recurrent wheeze in children at 3 y of age. (2007, methodology): “Concurrent with this population-based study, Xystrakis et al (37) in London administered vitamin D to a small group of healthy persons and steroid-resistant asthmatic patients and found that the intervention enhanced subsequent responsiveness to dexamethasone for induction of interleukin (IL)-10.”