Unconventional Rac-GEF activity is mediated through the Dock180–ELMO complex

By Enrico Brugnera, L. Haney, Cynthia M. Grimsley, Mingjian Lu, S. Walk, A. Tosello-Trampont, I. Macara, H. Madhani, Gerald Fink, K. Ravichandran. Nature Cell Biology, 2002

619 citations recorded by the source corpus.

Subfields: Aging, Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/b97fb5ca3c5dcc04c0eecc466feb8f51c7b57c4f

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Aging

1. A. Hall

In Cell Biology

1. M. Raftopoulou
2. K. Ravichandran
3. M. Frame
4. A. Hall
5. Clare M. Waterman
6. V. Brunton
7. U. Lorenz
8. J. Parsons

In Molecular Biology

1. M. Raftopoulou
2. K. Ravichandran
3. M. Frame
4. A. Hall
5. U. Lorenz
6. J. Parsons
7. C. Der

Citations in the corpus

• Cell migration: Rho GTPases lead the way. (2004, background): “Two independent studies have now shed new light on this problem and identified an evolutionarily conserved domain, Docker/DHR-2, in the C-terminus of DOCK180 that can stimulate GTP loading on Rac (Brugnera et al., 2002; Cote and Vuori, 2002).”
• The role of focal-adhesion kinase in cancer — a new therapeutic opportunity (2005, background): “DOCK180, when associated with its binding partner engulfment and cell motility protein (ELMO), stimulates RAC1 activit”
• Paxillin: adapting to change. (2004, neutral): “via a Crk-Cas-DOCK180 signaling pathway (29, 126).”
• Focal adhesion kinase: the first ten years (2003, background): “Increasing evidence points to DOCK180 and related family members as direct activators of Rac (Brugnera et al., 2002; Gu et al., 2001; Meller et al., 2002).”
• BAI1 is an engulfment receptor for apoptotic cells upstream of the ELMO/Dock180/Rac module (2007, background): “D -s er in e P ho sp ho - Lse rin e PtdCho GST (1) RGD-TSR (2) RGE-TSR (3) RGD-∆TSR (4) RGE-∆TSR (5) 4321 5 TSRs C on tr ol + G S T + R G D -”
• Engulfment of apoptotic cells: signals for a good meal (2007, background): “Similarly, the overexpression of both ELMO1 and DOCK180 (but not ELMO1 alone) resulted in a strong increase in RAC-GTP levels in transfected fibroblasts, and both ELMO1 and DOCK180 co-localized to membrane ruffle”
• Mechanical Integration of Actin and Adhesion Dynamics in Cell Migration (2010, background): “In addition, tyrosine-phosphorylated p130cas and paxillin bind the adapter Crk, which in turn recruits the Rac GEF DOCK180 to promote Rac activation (Brugnera et al. 2002, Cote & Vuori 2002).”