BAI1 is an engulfment receptor for apoptotic cells upstream of the ELMO/Dock180/Rac module
By Daeho Park, A. Tosello-Trampont, Michael R. Elliott, Mingjian Lu, L. Haney, Zhong Ma, A. Klibanov, J. Mandell, K. Ravichandran. Nature, 2007
895 citations recorded by the source corpus.
Subfields: Immunology, Molecular Biology, Physiology
View Paper: https://www.semanticscholar.org/paper/705aae62b686def81f88d9597b09adf6963a2880
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In Immunology
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Citations in the corpus
- Astrocytes Control Synapse Formation, Function, and Elimination (2015, neutral): “Bai1 has been identified as a phagocytic receptor that is expressed by astrocytes, and acts upstream of these components (Park et al. 2007).”
- An Apoptotic 'Eat Me' Signal: Phosphatidylserine Exposure. (2015, background): “In particular, BAI1 and stabilin 2 were shown to signal via Rac1 when engulfing apoptotic cells [70,74].”
- Shaping cups into phagosomes and macropinosomes (2008, background): “A number of different surface ligands have been identified as signals for the ingestion of apoptotic cells by phagocytes and various receptors have been identified as wel”
- Engulfment of apoptotic cells: signals for a good meal (2007, background): “have recently identified BAI1 (brain angiogenesis inhibitor 1) as a membrane protein expressed by phagocytes that can directly and stereo-specifically recognize PtdSer exposed on apoptotic cell”